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Mouse models in COVID-19 research: analyzing the adaptive immune response.
Clever, Sabrina; Volz, Asisa.
  • Clever S; Institute of Virology, University of Veterinary Medicine Hannover, Hannover, Germany. Sabrina.Clever@tiho-hannover.de.
  • Volz A; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany. Sabrina.Clever@tiho-hannover.de.
Med Microbiol Immunol ; 2022 Jun 04.
Article in English | MEDLINE | ID: covidwho-2293557
ABSTRACT
The emergence of SARS-CoV-2, the severe acute respiratory syndrome coronavirus type 2 causing the COVID-19 pandemic, resulted in a major necessity for scientific countermeasures. Investigations revealing the exact mechanisms of the SARS-CoV-2 pathogenesis provide the basis for the development of therapeutic measures and protective vaccines against COVID-19. Animal models are inevitable for infection and pre-clinical vaccination studies as well as therapeutic testing. A well-suited animal model, mimicking the pathology seen in human COVID-19 patients, is an important basis for these investigations. Several animal models were already used during SARS-CoV-2 studies with different clinical outcomes after SARS-CoV-2 infection. Here, we give an overview of different animal models used in SARS-CoV-2 infection studies with a focus on the mouse model. Mice provide a well-established animal model for laboratory use and several different mouse models have been generated and are being used in SARS-CoV-2 studies. Furthermore, the analysis of SARS-CoV-2-specific T cells during infection and in vaccination studies in mice is highlighted.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: S00430-022-00735-8

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: S00430-022-00735-8