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Autoantibodies and autoimmune disorders in SARS-CoV-2 infection: pathogenicity and immune regulation.
Darmarajan, Thiviya; Paudel, Keshav Raj; Candasamy, Mayuren; Chellian, Jestin; Madheswaran, Thiagarajan; Sakthivel, Lakshmana Prabu; Goh, Bey Hing; Gupta, Piyush Kumar; Jha, Niraj Kumar; Devkota, Hari Prasad; Gupta, Gaurav; Gulati, Monica; Singh, Sachin Kumar; Hansbro, Philip Michael; Oliver, Brian Gregory George; Dua, Kamal; Chellappan, Dinesh Kumar.
  • Darmarajan T; School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Subang Jaya, Bandar Sunway, Selangor, Malaysia.
  • Paudel KR; Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW, 2007, Australia.
  • Candasamy M; Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Malaysia.
  • Chellian J; Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Malaysia.
  • Madheswaran T; Department of Pharmaceutical Technology, School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Malaysia.
  • Sakthivel LP; Department of Pharmaceutical Technology, University College of Engineering (BIT Campus), Anna University, Tiruchirappalli, 620024, India.
  • Goh BH; Biofunctional Molecule Exploratory Research Group, School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor Darul Ehsan, 47500, Malaysia.
  • Gupta PK; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
  • Jha NK; Department of Life Sciences, School of Basic Sciences and Research, Sharda University, Knowledge Park III, Greater Noida, 201310, Uttar Pradesh, India.
  • Devkota HP; Department of Biotechnology, School of Engineering & Technology, Sharda University, Knowledge Park III, Greater Noida, 201310, Uttar Pradesh, India.
  • Gupta G; Department of Biotechnology Engineering and Food Technology, Chandigarh University, Mohali, 140413, India.
  • Gulati M; Department of Biotechnology, School of Applied & Life Sciences (SALS), Uttaranchal University, Dehradun, 248007, India.
  • Singh SK; Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto City, Kumamoto, 862-0973, Japan.
  • Hansbro PM; Program for Leading Graduate Schools, Health Life Science: Interdisciplinary and Glocal Oriented (HIGO) Program, 5-1 Oe-honmachi, Chuo-ku, Kumamoto, 862-0973, Japan.
  • Oliver BGG; School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur, India.
  • Dua K; Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
  • Chellappan DK; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India.
Environ Sci Pollut Res Int ; 29(36): 54072-54087, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-1877927
ABSTRACT
Coronavirus disease 2019 (COVID-19) is an infectious disease associated with the respiratory system caused by the SARS-CoV-2 virus. The aim of this review article is to establish an understanding about the relationship between autoimmune conditions and COVID-19 infections. Although majority of the population have been protected with vaccines against this virus, there is yet a successful curative medication for this disease. The use of autoimmune medications has been widely considered to control the infection, thus postulating possible relationships between COVID-19 and autoimmune diseases. Several studies have suggested the correlation between autoantibodies detected in patients and the severity of the COVID-19 disease. Studies have indicated that the SARS-CoV-2 virus can disrupt the self-tolerance mechanism of the immune system, thus triggering autoimmune conditions. This review discusses the current scenario and future prospects of promising therapeutic strategies that may be employed to regulate such autoimmune conditions.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoimmune Diseases / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Environ Sci Pollut Res Int Journal subject: Environmental Health / Toxicology Year: 2022 Document Type: Article Affiliation country: S11356-022-20984-7

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoimmune Diseases / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Environ Sci Pollut Res Int Journal subject: Environmental Health / Toxicology Year: 2022 Document Type: Article Affiliation country: S11356-022-20984-7