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Neuromuscular complications after COVID-19 vaccination: a series of eight patients.
Leemans, Wouter; Antonis, Sofie; De Vooght, Wouter; Lemmens, Robin; Van Damme, Philip.
  • Leemans W; Department of Neurology, University Hospitals Leuven, Leuven, Belgium.
  • Antonis S; Department of Neurology, Sint-Trudo Hospital, Sint-Truiden, Belgium.
  • De Vooght W; Department of Neurology, Sint-Trudo Hospital, Sint-Truiden, Belgium.
  • Lemmens R; Department of Neurology, University Hospitals Leuven, Leuven, Belgium.
  • Van Damme P; Department of Neurosciences, KU Leuven-University of Leuven, Experimental Neurology, and Leuven Brain Institute (LBI), Leuven, Belgium.
Acta Neurol Belg ; 122(3): 753-761, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-1877997
ABSTRACT

BACKGROUND:

Several neurologic complications have been reported in close temporal association with both severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and following vaccination against SARS-CoV-2. Specifically, several cases of Guillain-Barré syndrome (GBS) have been reported in temporal relationship with COVID-19 vaccination, with two small case series describing a specific phenotype with bifacial weakness and paresthesia in the limbs.

METHODS:

We retrospectively collected patients who developed a new-onset neuromuscular disorder in the first 6 weeks after receiving a COVID-19 vaccine (either first or second dose). The patients were collected from one tertiary care centre and one secondary care centre from February to July 2021.

RESULTS:

We report eight patients who developed phenotypically diverse neuromuscular disorders in the weeks following COVID-19 vaccination, with a presumed immune-mediated etiology. In our case series, we report three patients with classical GBS, one patient with bifacial weakness with paresthesia variant of GBS, two patients with subacute-onset chronic inflammatory demyelinating polyneuropathy (CIDP), one patient with brachial plexopathy and one patient with subacute axonal sensorimotor polyneuropathy.

CONCLUSIONS:

New-onset neuromuscular disorders with onset in the weeks after COVID-19 vaccination can include diverse phenotypes. A causal relationship between these disorders and the vaccine cannot be proven at present, and further epidemiological studies are needed to further investigate this association.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Guillain-Barre Syndrome / COVID-19 Vaccines / COVID-19 Type of study: Case report / Etiology study / Observational study Topics: Long Covid / Vaccines / Variants Limits: Humans Language: English Journal: Acta Neurol Belg Year: 2022 Document Type: Article Affiliation country: S13760-022-01941-0

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Guillain-Barre Syndrome / COVID-19 Vaccines / COVID-19 Type of study: Case report / Etiology study / Observational study Topics: Long Covid / Vaccines / Variants Limits: Humans Language: English Journal: Acta Neurol Belg Year: 2022 Document Type: Article Affiliation country: S13760-022-01941-0