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Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2.
Fang, Zhenhao; Peng, Lei; Filler, Renata; Suzuki, Kazushi; McNamara, Andrew; Lin, Qianqian; Renauer, Paul A; Yang, Luojia; Menasche, Bridget; Sanchez, Angie; Ren, Ping; Xiong, Qiancheng; Strine, Madison; Clark, Paul; Lin, Chenxiang; Ko, Albert I; Grubaugh, Nathan D; Wilen, Craig B; Chen, Sidi.
  • Fang Z; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.
  • Peng L; System Biology Institute, Yale University, West Haven, CT, USA.
  • Filler R; Center for Cancer Systems Biology, Yale University, West Haven, CT, USA.
  • Suzuki K; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.
  • McNamara A; System Biology Institute, Yale University, West Haven, CT, USA.
  • Lin Q; Center for Cancer Systems Biology, Yale University, West Haven, CT, USA.
  • Renauer PA; Department of Laboratory Medicine, Yale University, New Haven, CT, USA.
  • Yang L; Department of Immunobiology, Yale University, New Haven, CT, USA.
  • Menasche B; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.
  • Sanchez A; System Biology Institute, Yale University, West Haven, CT, USA.
  • Ren P; Center for Cancer Systems Biology, Yale University, West Haven, CT, USA.
  • Xiong Q; Department of Laboratory Medicine, Yale University, New Haven, CT, USA.
  • Strine M; Department of Immunobiology, Yale University, New Haven, CT, USA.
  • Clark P; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.
  • Lin C; System Biology Institute, Yale University, West Haven, CT, USA.
  • Ko AI; Center for Cancer Systems Biology, Yale University, West Haven, CT, USA.
  • Grubaugh ND; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.
  • Wilen CB; System Biology Institute, Yale University, West Haven, CT, USA.
  • Chen S; Center for Cancer Systems Biology, Yale University, West Haven, CT, USA.
Nat Commun ; 13(1): 3250, 2022 06 06.
Article in English | MEDLINE | ID: covidwho-1878526
ABSTRACT
The Omicron variant of SARS-CoV-2 recently swept the globe and showed high level of immune evasion. Here, we generate an Omicron-specific lipid nanoparticle (LNP) mRNA vaccine candidate, and test its activity in animals, both alone and as a heterologous booster to WT mRNA vaccine. Our Omicron-specific LNP-mRNA vaccine elicits strong antibody response in vaccination-naïve mice. Mice that received two-dose WT LNP-mRNA show a > 40-fold reduction in neutralization potency against Omicron than WT two weeks post boost, which further reduce to background level after 3 months. The WT or Omicron LNP-mRNA booster increases the waning antibody response of WT LNP-mRNA vaccinated mice against Omicron by 40 fold at two weeks post injection. Interestingly, the heterologous Omicron booster elicits neutralizing titers 10-20 fold higher than the homologous WT booster against Omicron variant, with comparable titers against Delta variant. All three types of vaccination, including Omicron alone, WT booster and Omicron booster, elicit broad binding antibody responses against SARS-CoV-2 WA-1, Beta, Delta variants and SARS-CoV. These data provide direct assessments of an Omicron-specific mRNA vaccination in vivo, both alone and as a heterologous booster to WT mRNA vaccine.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines / Variants Limits: Animals Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-30878-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines / Variants Limits: Animals Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-30878-4