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Correlates of protection against SARS-CoV-2 infection and COVID-19 disease.
Goldblatt, David; Alter, Galit; Crotty, Shane; Plotkin, Stanley A.
  • Goldblatt D; Great Ormond Street Institute of Child Health, University College London, London, UK.
  • Alter G; Massachusetts General Hospital, Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA.
  • Crotty S; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, California, USA.
  • Plotkin SA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California San Diego (UCSD), La Jolla, California, USA.
Immunol Rev ; 310(1): 6-26, 2022 09.
Article in English | MEDLINE | ID: covidwho-1879045
ABSTRACT
Antibodies against epitopes in S1 give the most accurate CoP against infection by the SARS-CoV-2 coronavirus. Measurement of those antibodies by neutralization or binding assays both have predictive value, with binding antibody titers giving the highest statistical correlation. However, the protective functions of antibodies are multiple. Antibodies with multiple functions other than neutralization influence efficacy. The role of cellular responses can be discerned with respect to CD4+ T cells and their augmentation of antibodies, and with respect to CD8+ cells with regard to control of viral replication, particularly in the presence of insufficient antibody. More information is needed on mucosal responses.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Prognostic study Limits: Humans Language: English Journal: Immunol Rev Year: 2022 Document Type: Article Affiliation country: Imr.13091

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Prognostic study Limits: Humans Language: English Journal: Immunol Rev Year: 2022 Document Type: Article Affiliation country: Imr.13091