Correlates of protection against SARS-CoV-2 infection and COVID-19 disease.
Immunol Rev
; 310(1): 6-26, 2022 09.
Article
in English
| MEDLINE | ID: covidwho-1879045
ABSTRACT
Antibodies against epitopes in S1 give the most accurate CoP against infection by the SARS-CoV-2 coronavirus. Measurement of those antibodies by neutralization or binding assays both have predictive value, with binding antibody titers giving the highest statistical correlation. However, the protective functions of antibodies are multiple. Antibodies with multiple functions other than neutralization influence efficacy. The role of cellular responses can be discerned with respect to CD4+ T cells and their augmentation of antibodies, and with respect to CD8+ cells with regard to control of viral replication, particularly in the presence of insufficient antibody. More information is needed on mucosal responses.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antibodies, Neutralizing
/
Spike Glycoprotein, Coronavirus
/
SARS-CoV-2
/
COVID-19
/
Antibodies, Viral
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Immunol Rev
Year:
2022
Document Type:
Article
Affiliation country:
Imr.13091
Similar
MEDLINE
...
LILACS
LIS