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Factors Associated With Severe Illness in Patients Aged <21 Years Hospitalized for COVID-19.
Choudhary, Rewa; Webber, Bryant J; Womack, Lindsay S; Dupont, Hannah K; Chiu, Sophia K; Wanga, Valentine; Gerdes, Megan E; Hsu, Sophia; Shi, Dallas S; Dulski, Theresa M; Idubor, Osatohamwen I; Wendel, Arthur M; Agathis, Nickolas T; Anderson, Kristi; Boyles, Tricia; Click, Eleanor S; Silva, Juliana Da; Evans, Mary E; Gold, Jeremy A W; Haston, Julia C; Logan, Pamela; Maloney, Susan A; Martinez, Marisol; Natarajan, Pavithra; Spicer, Kevin B; Swancutt, Mark; Stevens, Valerie A; Rogers-Brown, Jessica; Chandra, Gyan; Light, Megan; Barr, Frederick E; Snowden, Jessica; Kociolek, Larry K; McHugh, Matthew; Wessel, David L; Simpson, Joelle N; Gorman, Kathleen C; Breslin, Kristen A; DeBiasi, Roberta L; Thompson, Aaron; Kline, Mark W; Boom, Julie A; Singh, Ila R; Dowlin, Michael; Wietecha, Mark; Schweitzer, Beth; Morris, Sapna Bamrah; Koumans, Emilia H; Ko, Jean Y; Siegel, David A.
  • Choudhary R; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Webber BJ; Epidemic Intelligence Service, CDC, Atlanta, Georgia.
  • Womack LS; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Dupont HK; Epidemic Intelligence Service, CDC, Atlanta, Georgia.
  • Chiu SK; Air Force Institute of Technology, Wright-Patterson AFB, Ohio.
  • Wanga V; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Gerdes ME; United States Public Health Service, Commissioned Corps, Rockville, Maryland.
  • Hsu S; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Shi DS; United States Public Health Service, Commissioned Corps, Rockville, Maryland.
  • Dulski TM; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Idubor OI; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Wendel AM; Epidemic Intelligence Service, CDC, Atlanta, Georgia.
  • Agathis NT; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Anderson K; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Boyles T; United States Public Health Service, Commissioned Corps, Rockville, Maryland.
  • Click ES; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Silva JD; Epidemic Intelligence Service, CDC, Atlanta, Georgia.
  • Evans ME; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Gold JAW; Epidemic Intelligence Service, CDC, Atlanta, Georgia.
  • Haston JC; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Logan P; United States Public Health Service, Commissioned Corps, Rockville, Maryland.
  • Maloney SA; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Martinez M; United States Public Health Service, Commissioned Corps, Rockville, Maryland.
  • Natarajan P; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Spicer KB; Epidemic Intelligence Service, CDC, Atlanta, Georgia.
  • Swancutt M; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Stevens VA; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Rogers-Brown J; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Chandra G; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Light M; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Barr FE; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Snowden J; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Kociolek LK; Epidemic Intelligence Service, CDC, Atlanta, Georgia.
  • McHugh M; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Wessel DL; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Simpson JN; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Gorman KC; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Breslin KA; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • DeBiasi RL; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Thompson A; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Kline MW; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Boom JA; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Singh IR; COVID-19 Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Dowlin M; Arkansas Children's, Little Rock, Arkansas.
  • Wietecha M; Arkansas Children's, Little Rock, Arkansas.
  • Schweitzer B; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
  • Morris SB; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
  • Koumans EH; Children's National Hospital, Washington, DC.
  • Ko JY; Children's National Hospital, Washington, DC.
  • Siegel DA; Children's National Hospital, Washington, DC.
Hosp Pediatr ; 2022 Jun 08.
Article in English | MEDLINE | ID: covidwho-1879346
ABSTRACT

OBJECTIVES:

To describe COVID-19-related pediatric hospitalizations during a period of B.1.617.2 (Delta) variant predominance and to determine age-specific factors associated with severe illness. PATIENTS AND

METHODS:

We abstracted data from medical charts to conduct a cross-sectional study of patients aged <21 years hospitalized at 6 US children's hospitals during July-August 2021 for COVID-19 or with an incidental positive SARS-CoV-2 test. Among patients with COVID-19, we assessed factors associated with severe illness by calculating age-stratified prevalence ratios (PR). We defined severe illness as receiving high-flow nasal cannula, positive airway pressure, or invasive mechanical ventilation.

RESULTS:

Of 947 hospitalized patients, 759 (80.1%) had COVID-19, of whom 287 (37.8%) had severe illness. Factors associated with severe illness included coinfection with RSV (PR 3.64) and bacteria (PR 1.88) in infants; RSV coinfection in patients aged 1-4 years (PR 1.96); and obesity in patients aged 5-11 (PR 2.20) and 12-17 years (PR 2.48). Having ≥2 underlying medical conditions was associated with severe illness in patients aged <1 (PR 1.82), 5-11 (PR 3.72), and 12-17 years (PR 3.19).

CONCLUSIONS:

Among patients hospitalized for COVID-19, factors associated with severe illness included RSV coinfection in those aged <5 years, obesity in those aged 5-17 years, and other underlying conditions for all age groups <18 years. These findings can inform pediatric practice, risk communication, and prevention strategies, including vaccination against COVID-19.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Randomized controlled trials / Risk factors Topics: Vaccines / Variants Language: English Year: 2022 Document Type: Article Affiliation country: Hpeds.2022-006613

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Randomized controlled trials / Risk factors Topics: Vaccines / Variants Language: English Year: 2022 Document Type: Article Affiliation country: Hpeds.2022-006613