Vinpocetine is the forthcoming adjuvant agent in the management of COVID-19.
Future Sci OA
; 8(5): FSO797, 2022 Mar.
Article
in English
| MEDLINE | ID: covidwho-1879356
ABSTRACT
Vinpocetine (VPN) is an alkaloid derivative of vincamine inhibits phosphodiesterase type 1 that increase cyclic guanosine monophosphate and cyclic adenosine monophosphate. VPN have anti-inflammatory and antioxidant effects with suppression release of pro-inflammatory cytokines. Moreover, VPN mitigates oxidative stress (OS) and inflammatory reactions through inhibition of mitogen-activated protein kinase (MAPK) signaling pathway. Therefore, VPN may decrease hyper-inflammation-induced acute lung injury in COVID-19 through modulation of NF-κB pathway. Taken together, VPN has pulmonary and extra-pulmonary protective effects against COVID-19 through mitigation of OS and hyperinflammation. In conclusion, VPN has noteworthy anti-inflammatory and anti-oxidant effects through inhibition of NF-κB/MAPK signaling pathway so, it may reduce SARS-CoV-2-induced hyper inflammatory and OS.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Language:
English
Journal:
Future Sci OA
Year:
2022
Document Type:
Article
Affiliation country:
Fsoa-2021-0099
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