Insights into Coronavirus Papain-like Protease Structure, Function and Inhibitors.
Protein Pept Lett
; 29(7): 574-583, 2022.
Article
in English
| MEDLINE | ID: covidwho-1879360
ABSTRACT
The coronavirus family consists of pathogens that seriously affect human and animal health. They mostly cause respiratory or enteric diseases, which can be severe and life-threatening, such as coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome (SARS), and Middle East Respiratory Syndrome (MERS) in humans. The conserved coronaviral papain-like protease is an attractive antiviral drug target because it is essential for coronaviral replication, and it also inhibits host innate immune responses. This review focuses on the latest research progress relating to the mechanism of coronavirus infection, the structural and functional characteristics of coronavirus papain-like protease, and the potent inhibitors of the protease.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Coronavirus Infections
/
Coronavirus Papain-Like Proteases
Limits:
Animals
/
Humans
Language:
English
Journal:
Protein Pept Lett
Journal subject:
Biochemistry
Year:
2022
Document Type:
Article
Affiliation country:
0929866529666220602094016
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