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SARS-CoV-2 in Kidney Transplant Patients: A Real-Life Experience.
Pinchera, Biagio; Spirito, Lorenzo; Ferreri, Lucia; Rocca, Roberto La; Celentano, Giuseppe; Buonomo, Antonio Riccardo; Foggia, Maria; Scotto, Riccardo; Federico, Stefano; Gentile, Ivan; Carrano, Rosa.
  • Pinchera B; Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy.
  • Spirito L; Department of Neurosciences, Reproductive and Odontostomatological Sciences, Section of Urology, University of Naples "Federico II", Naples, Italy.
  • Ferreri L; Department of Public Health, University of Naples "Federico II", Naples, Italy.
  • Rocca R; Department of Neurosciences, Reproductive and Odontostomatological Sciences, Section of Urology, University of Naples "Federico II", Naples, Italy.
  • Celentano G; Department of Neurosciences, Reproductive and Odontostomatological Sciences, Section of Urology, University of Naples "Federico II", Naples, Italy.
  • Buonomo AR; Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy.
  • Foggia M; Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy.
  • Scotto R; Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy.
  • Federico S; Department of Public Health, University of Naples "Federico II", Naples, Italy.
  • Gentile I; Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy.
  • Carrano R; Department of Public Health, University of Naples "Federico II", Naples, Italy.
Front Med (Lausanne) ; 9: 864865, 2022.
Article in English | MEDLINE | ID: covidwho-1879460
ABSTRACT

Background:

The COVID-19 pandemic has significantly impacted the management of solid organ transplant recipients and on clinical evolution in post-transplantation. Little is known on the impact of SARS-CoV-2 infection in these patients. The severity and lethality of this disease in solid organ transplant patients are higher thanin the general population. This study aims to describe clinical characteristics of SARS-CoV-2 infection in solid organ transplant recipients followed in our center.

Methods:

In this observational study, we enrolled all kidney transplant recipientsattending the A.O.U. Federico II of Naples from March 2020 to January 2021. For each patient we evaluated the epidemiological and clinical characteristics as well as outcome.

Results:

We enrolled 369 kidney transplant patients (229, male, 62%). Of these, 51 (13.8%) acquired SARS-CoV-2 infection and 29 showed symptomatic disease. Of the 51 patients with the infection, 48 (94.11%) had at least one comorbidity and such comorbidities did not constitute a risk factor for a more severe disease. Hospitalization was necessary for 7 (13.7%) patients. Of these, 2 required low-flow oxygen supplementation, 3 non-invasive/high flow ventilation and 2 invasive ventilation. Finally, 2 patients died.

Conclusions:

Our study shows a lower mortality and hospitalization rate compared to figures available in the literature (4% vs. 13-30% and 14% vs. 32-100%, respectively). Furthermore, the comorbidities examined (hypertension, dyslipidemia, and diabetes) did not constitute a risk factor for a more severe disease condition in this patient category. Further studies with larger sample size are necessary to confirm these data.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Language: English Journal: Front Med (Lausanne) Year: 2022 Document Type: Article Affiliation country: Fmed.2022.864865

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Language: English Journal: Front Med (Lausanne) Year: 2022 Document Type: Article Affiliation country: Fmed.2022.864865