SARS-CoV-2 variants: Relevance for symptom granularity, epidemiology, immunity (herd, vaccines), virus origin and containment?
Environ Microbiol
; 22(6): 2001-2006, 2020 06.
Article
in English
| MEDLINE | ID: covidwho-187999
ABSTRACT
The origin of the SARS-CoV-2 virus remains enigmatic. It is likely to be a continuum resulting from inevitable mutations and recombination events. These genetic changes keep developing in the present epidemic. Mutations tending to deplete the genome in its cytosine content will progressively lead to attenuation as a consequence of Muller's ratchet, but this is counteracted by recombination when different mutants co-infect the same host, in particular, in clusters of infection. Monitoring as a function of time the genome sequences in closely related cases is critical to anticipate the future of SARS-CoV-2 and hence of COVID-19.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
Type of study:
Observational study
Topics:
Vaccines
/
Variants
Limits:
Humans
Language:
English
Journal:
Environ Microbiol
Journal subject:
Microbiology
/
Environmental Health
Year:
2020
Document Type:
Article
Affiliation country:
1462-2920.15053
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