Laboratory predictors for COVID-19 Intensive Care Unit admissions in Trinidad and Tobago.
Dialogues Health
; 1: 100022, 2022 Dec.
Article
in English
| MEDLINE | ID: covidwho-1881908
ABSTRACT
Understanding symptoms associated with COVID-19 cases requiring intensive care unit(ICU) attention is important in management of the life-threatening cases of the disease. This study aimed to determine laboratory indicators of ICU admission for COVID-19 patients. For this retrospective chart review study, data from 116 patients(ICU, nâ¯=â¯18, Non-ICU, nâ¯=â¯98) with confirmed SARS-CoV-2, managed at two hospitals in Trinidad and Tobago, from March 12th to April 12th 2020, were analyzed. The median age of non-ICU patients was 59.0(IQRâ¯=â¯23.5) years; ICU patients had a median age of 62.5(IRâ¯=â¯17.5). From univariate analysis, laboratory indicators significantly associated with ICU admission included WBC(Pâ¯=â¯0.037), lymphocyte(Pâ¯=â¯0.016), LDH(Pâ¯=â¯0.002), AST(Pâ¯=â¯0.005) and CRP(Pâ¯=â¯0.0001). However, multivariate analysis including WBC, neutrophil, lymphocyte, PLT, AST, LDH, ALT and CRP indicated that only AST was associated with high odds of ICU admission(OR 0.002, 95% CI 0.000-0.004, Pâ¯=â¯0.017). Statistically significant AUC were obtained for neutrophil(AUCâ¯=â¯0.704, Pâ¯=â¯0.007), CRP (AUCâ¯=â¯0.81, pâ¯=â¯0.00) and LDH(AUCâ¯=â¯0.766, Pâ¯=â¯0.00) and AST (AUCâ¯=â¯0.729, Pâ¯=â¯0.003). The findings indicate that neutrophils, AST and LDH's ROC curves are good tests, CRP curve is a very good test, but lymphocyte curve is a poor test, in determining COVID-19 patients for ICU admission. Neutrophil, AST, LDH and CRP are suitable predictors of COVID-19 patients that should receive intensive unit care. The study provides significant insights into laboratory parameters that can be used to predict COVID-19 severity and important considerations for healthcare providers in making evidence-based decisions regarding COVID-19 patient management, especially in the context of limited ICU facilities. This study was not funded.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Observational study
/
Prognostic study
Country/Region as subject:
English Caribbean
/
Trinidad and Tobago
Language:
English
Journal:
Dialogues Health
Year:
2022
Document Type:
Article
Affiliation country:
J.DIALOG.2022.100022
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