Clinical impact and disease evolution of SARS-CoV-2 infection in familial Mediterranean fever.
Pharmacol Res
; 182: 106293, 2022 08.
Article
in English
| MEDLINE | ID: covidwho-1882440
ABSTRACT
The innate immune system is critically involved in the pathogenesis of familial Mediterranean fever (FMF), characterized by dysregulated inflammasome activity and recurrent inflammatory attacks this is the most common among monogenic autoinflammatory diseases, which shares some biochemical pathways with the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection. In this short review we explore the overlap in the pathophysiology of FMF and SARS-CoV-2 infection, discussing how to understand better the interaction between the two diseases and optimize management. A poorer outcome of SARS-CoV-2 infection seems not to be present in infected FMF patients in terms of hospitalization time, need for oxygen support, need for intensive care, rate of complications and exitus. Long-term surveillance will confirm the relatively low risk of a worse prognosis observed so far in SARS-CoV-2-infected people with FMF. In these patients COVID-19 vaccines are recommended and their safety profile is expected to be similar to the general population.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Familial Mediterranean Fever
/
COVID-19
Type of study:
Experimental Studies
/
Prognostic study
Topics:
Long Covid
/
Vaccines
Limits:
Humans
Language:
English
Journal:
Pharmacol Res
Journal subject:
Pharmacology
Year:
2022
Document Type:
Article
Affiliation country:
J.phrs.2022.106293
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