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SARS-CoV-2 anti-spike antibody levels following second dose of ChAdOx1 nCov-19 or BNT162b2 in residents of long-term care facilities in England (VIVALDI).
Stirrup, Oliver; Krutikov, Maria; Tut, Gokhan; Palmer, Tom; Bone, David; Bruton, Rachel; Fuller, Chris; Azmi, Borscha; Lancaster, Tara; Sylla, Panagiota; Kaur, Nayandeep; Spalkova, Eliska; Bentley, Christopher; Amin, Umayr; Jadir, Azar; Hulme, Samuel; Giddings, Rebecca; Nacer-Laidi, Hadjer; Baynton, Verity; Irwin-Singer, Aidan; Hayward, Andrew; Moss, Paul; Copas, Andrew; Shallcross, Laura.
  • Stirrup O; UCL Institute for Global Health, London, WC1N 1EH, United Kingdom.
  • Krutikov M; UCL Institute of Health Informatics, London, NW1 2DA, United Kingdom.
  • Tut G; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
  • Palmer T; UCL Institute for Global Health, London, WC1N 1EH, United Kingdom.
  • Bone D; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
  • Bruton R; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
  • Fuller C; UCL Institute of Health Informatics, London, NW1 2DA, United Kingdom.
  • Azmi B; UCL Institute of Health Informatics, London, NW1 2DA, United Kingdom.
  • Lancaster T; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
  • Sylla P; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
  • Kaur N; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
  • Spalkova E; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
  • Bentley C; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
  • Amin U; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
  • Jadir A; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
  • Hulme S; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
  • Giddings R; UCL Institute of Health Informatics, London, NW1 2DA, United Kingdom.
  • Nacer-Laidi H; UCL Institute of Health Informatics, London, NW1 2DA, United Kingdom.
  • Baynton V; Department of Health and Social Care, London, SW1H 0EU, United Kingdom.
  • Irwin-Singer A; Department of Health and Social Care, London, SW1H 0EU, United Kingdom.
  • Hayward A; UCL Institute of Epidemiology & Health Care, London, WC1E 7HB, United Kingdom.
  • Moss P; Health Data Research UK, London, United Kingdom.
  • Copas A; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
  • Shallcross L; UCL Institute for Global Health, London, WC1N 1EH, United Kingdom.
J Infect Dis ; 2022 Apr 16.
Article in English | MEDLINE | ID: covidwho-1883018
ABSTRACT
General population studies have shown strong humoral response following SARS-CoV-2 vaccination with subsequent waning of anti-spike antibody levels. Vaccine-induced immune responses are often attenuated in frail and older populations, but published data are scarce. We measured SARS-CoV-2 anti-spike antibody levels in Long-Term Care Facility residents and staff following second vaccination dose with Oxford-AstraZeneca or Pfizer-BioNTech. Vaccination elicited robust antibody responses in older residents, suggesting comparable levels of vaccine-induced immunity to that in the general population. Antibody levels are higher after Pfizer-BioNTech vaccination but fall more rapidly compared to Oxford-AstraZeneca recipients and are enhanced by prior infection in both groups.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Randomized controlled trials Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Randomized controlled trials Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Infdis