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Lactobacilli reduce recurrences of vaginal candidiasis in pregnant women: a randomized, double-blind, placebo-controlled study.
Ang, X-Y; Chung, F-Y-L; Lee, B-K; Azhar, S N A; Sany, S; Roslan, N S; Ahmad, N; Yusof, S M; Abdullah, N; Nik Ab Rahman, N N; Abdul Wahid, N; Deris, Z Z; Oon, C-E; Wan Adnan, W F; Liong, M-T.
  • Ang XY; School of Industrial Technology, Universiti Sains Malaysia, Penang, Malaysia.
  • Chung FY; School of Industrial Technology, Universiti Sains Malaysia, Penang, Malaysia.
  • Lee BK; School of Industrial Technology, Universiti Sains Malaysia, Penang, Malaysia.
  • Azhar SNA; School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
  • Sany S; Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang, Malaysia.
  • Roslan NS; School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
  • Ahmad N; Hospital Universiti Sains Malaysia (HUSM), Health Campus, Kelantan, Malaysia.
  • Yusof SM; Kota Bharu Health Clinic, Ministry of Health Malaysia, Kelantan, Malaysia.
  • Abdullah N; Kubang Kerian Health Clinic, Ministry of Health Malaysia, Kelantan, Malaysia.
  • Nik Ab Rahman NN; Pengkalan Chepa Health Clinic, Ministry of Health Malaysia, Kelantan, Malaysia.
  • Abdul Wahid N; Wakaf Che Yeh Health Clinic, Ministry of Health Malaysia, Kelantan, Malaysia.
  • Deris ZZ; Sejahtera Centre, Universiti Sains Malaysia, Penang, Malaysia.
  • Oon CE; School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
  • Wan Adnan WF; Hospital Universiti Sains Malaysia (HUSM), Health Campus, Kelantan, Malaysia.
  • Liong MT; Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Penang, Malaysia.
J Appl Microbiol ; 132(4): 3168-3180, 2022 Apr.
Article in English | MEDLINE | ID: covidwho-1883208
ABSTRACT

AIMS:

The aim of this study was to investigate the effects of lactobacilli strains in preventing the recurrences of vaginal candidiasis (VC) in 78 pregnant women with VC (lactobacilli, n = 39; placebo, n = 39) and the potential benefits on quality of life. METHODS AND

RESULTS:

The lactobacilli putative probiotic (SynForU-HerCare; two capsules/day of 9·5 log CFU per capsule) or placebo was administered for 8-weeks in a randomized, double-blind, placebo-controlled study. Subjects were assessed for vaginal and gut health conditions at baseline, week-4 and week-8 via questionnaires. The vulvovaginal symptom questionnaire not only covered aspects pertaining to vulvovaginal symptoms but also the quality of life impacts such as emotional, social and sexual. The administration of lactobacilli reduced symptoms of irritation (P = 0·023) and discharge (P = 0·011) starting week-4 and continued after week-8 (P < 0·05), accompanied by reduced symptoms for burning after week-8 (P = 0·046) as compared to the placebo. Patients consuming lactobacilli also showed reduced concern about symptoms after week-4 (P = 0·010) and continued after week-8 (P = 0·001), accompanied by reduced impairment of daily activities attributed to vulvovaginal symptoms (P = 0·012) and continued after week-8 (P = 0·026). Insignificant differences were observed for sexual impacts between treatment groups. The administration of lactobacilli also reduced recurrences of both emotional and social stress as compared to the placebo at both week-4 and week-8 (P < 0·05). Patients consuming lactobacilli showed higher defecation times per week at week-4 (P = 0·010) and week-8 (P = 0·001) as compared to the placebo group, indicating the potential to reduce risks of pregnancy-induced constipation.

CONCLUSIONS:

Lactobacilli probiotics are beneficial towards pregnant women, especially in reducing vulvovaginal symptoms and recurrences of VC, accompanied by improved emotional and social distress attributed to VC. SIGNIFICANCE AND IMPACT OF THE STUDY The study demonstrated the preventive and modulatory roles of lactobacilli strains against VC in pregnant women. Taken altogether, our present data illustrated that lactobacilli probiotics are beneficial towards pregnant women, especially in reducing vulvovaginal symptoms and recurrences of VC, accompanied by improved emotional and social distress attributed to VC, thus could be a potential strategy for the maintenance of vaginal health during pregnancy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Candidiasis, Vulvovaginal / Probiotics Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans / Pregnancy Language: English Journal: J Appl Microbiol Journal subject: Microbiology Year: 2022 Document Type: Article Affiliation country: Jam.15158

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Candidiasis, Vulvovaginal / Probiotics Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans / Pregnancy Language: English Journal: J Appl Microbiol Journal subject: Microbiology Year: 2022 Document Type: Article Affiliation country: Jam.15158