Categorizing Sequences of Concern by Function To Better Assess Mechanisms of Microbial Pathogenesis.
Infect Immun
; 90(5): e0033421, 2022 05 19.
Article
in English
| MEDLINE | ID: covidwho-1883264
ABSTRACT
To identify sequences with a role in microbial pathogenesis, we assessed the adequacy of their annotation by existing controlled vocabularies and sequence databases. Our goal was to regularize descriptions of microbial pathogenesis for improved integration with bioinformatic applications. Here, we review the challenges of annotating sequences for pathogenic activity. We relate the categorization of more than 2,750 sequences of pathogenic microbes through a controlled vocabulary called Functions of Sequences of Concern (FunSoCs). These allow for an ease of description by both humans and machines. We provide a subset of 220 fully annotated sequences in the supplemental material as examples. The use of this compact (â¼30 terms), controlled vocabulary has potential benefits for research in microbial genomics, public health, biosecurity, biosurveillance, and the characterization of new and emerging pathogens.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Vocabulary, Controlled
/
Computational Biology
Type of study:
Experimental Studies
Limits:
Humans
Language:
English
Journal:
Infect Immun
Year:
2022
Document Type:
Article
Affiliation country:
Iai.00334-21
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