Investigating COVID-19 Severity Based on Serum Apelin-17 Levels and Inflammatory Mediators
Current Respiratory Medicine Reviews
; 18(1):65-71, 2022.
Article
in English
| EMBASE | ID: covidwho-1883805
ABSTRACT
Background:
COVID-19 is an infectious disease caused by SARS-CoV-2 and can lead to acute respiratory distress.Objective:
We aimed to investigate the association between COVID-19 severity and serum apelin17 and inflammatory mediator levels.Methods:
This cross-sectional study was conducted on patients with COVID-19. COVID-19 infection was confirmed by the RT-PCR test. The patients' data were extracted from their records. Venous blood samples were obtained from the patients to investigate the serum levels of apelin-17 and inflammatory mediators.Results:
Eighty-six COVID-19 patients were studied. The mean age of the participants was 55.56±14.88, and 43 (50 %) were male. Clinical symptoms were dyspnea 77.6 %, fever 52.3 %, cough 48.8 %, gastrointestinal symptoms 15.1 %, and chest pain 7 %. The overall mortality rate was 7 %. No significant relationship was found between serum apelin-17 levels and COVID-19 severity (P= 0.48). However, there was a significant and direct relationship between COVID-19 severity and serum levels of CRP (P= 0.038) and D-dimer (P= 0.029).Conclusion:
Serum apelin-17 levels were higher in recovered patients than those who died (4.90 vs. 3.19). Moreover, serum apelin-17 levels were higher in the patients admitted to the general ward than those admitted to the ICU (5.15 vs. 3.98). The difference was not statistically significant. However, there was a significant and direct relationship between serum apelin-17 levels and lymphocyte count (P= 0.022). Moreover, there was a significant and inverse relationship between lymphocyte count and COVID-19 severity (P= 0.004). Therefore, it can be interpreted that COVID-19 severity may decrease with an increase in serum apelin-17 levels. Therefore, to prove this hypothesis, a study with larger sample size is recommended.
adult; all cause mortality; article; blood sampling; controlled study; coronavirus disease 2019; coughing; cross-sectional study; dyspnea; female; fever; gastrointestinal symptom; gene expression; human; human tissue; lymphocyte count; major clinical study; male; middle aged; pneumonia; protein blood level; protein expression; sample size; thorax pain; venous blood; apelin; C reactive protein; D dimer; endogenous compound
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Prognostic study
Language:
English
Journal:
Current Respiratory Medicine Reviews
Year:
2022
Document Type:
Article
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