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Neutrophils Actively Contribute to Obesity-Associated Inflammation and Pathological Complications.
Uribe-Querol, Eileen; Rosales, Carlos.
  • Uribe-Querol E; Laboratorio de Biología del Desarrollo, División de Estudios de Posgrado e Investigación, Facultad de Odontología, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
  • Rosales C; Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
Cells ; 11(12)2022 06 10.
Article in English | MEDLINE | ID: covidwho-1884017
ABSTRACT
Obesity is characterized by an increase in body weight associated with an exaggerated enlargement of the adipose tissue. Obesity has serious negative effects because it is associated with multiple pathological complications such as type 2 diabetes mellitus, cardiovascular diseases, cancer, and COVID-19. Nowadays, 39% of the world population is obese or overweight, making obesity the 21st century epidemic. Obesity is also characterized by a mild, chronic, systemic inflammation. Accumulation of fat in adipose tissue causes stress and malfunction of adipocytes, which then initiate inflammation. Next, adipose tissue is infiltrated by cells of the innate immune system. Recently, it has become evident that neutrophils, the most abundant leukocytes in blood, are the first immune cells infiltrating the adipose tissue. Neutrophils then get activated and release inflammatory factors that recruit macrophages and other immune cells. These immune cells, in turn, perpetuate the inflammation state by producing cytokines and chemokines that can reach other parts of the body, creating a systemic inflammatory condition. In this review, we described the recent findings on the role of neutrophils during obesity and the initiation of inflammation. In addition, we discuss the involvement of neutrophils in the generation of obesity-related complications using diabetes as a prime example.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Insulin Resistance / Diabetes Mellitus, Type 2 / COVID-19 Topics: Long Covid Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Cells11121883

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Insulin Resistance / Diabetes Mellitus, Type 2 / COVID-19 Topics: Long Covid Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Cells11121883