Association between Periodontitis and COVID-19 Based on Severity Scores of HRCT Chest Scans.

ABSTRACT

BACKGROUND: A relationship between periodontitis and COVID-19 may exist, as highlighted by several hypothetical models. However, the evidence is limited. Hence, the present study was conducted to determine whether an association exists between periodontitis and COVID-19. METHODS: A cross-sectional study was carried out with patients diagnosed with COVID-19 who were divided into three groups-mild, moderate, and severe COVID-19-based on the COVID-19 severity score of high-resolution computed tomography (HRCT) chest scans. Periodontal parameters-including the plaque index (PI), ratio of sites with gingival bleeding (BOP), pocket depth (PD), gingival recession (REC), clinical attachment loss (CAL), and mean numbers of mobile and missing teeth due to periodontitis-were recorded for all three groups. Statistical analyses were applied to the data. RESULTS: Of 294 patients with COVID-19, approximately 50.68% (n = 149) had periodontitis, and the highest percentage (87.5%) was reported in the severe COVID-19 group. Additionally, severe and advanced stages of periodontitis (stage III-IV) were found to be significantly more frequent in subjects with severe COVID-19 than in the other two groups. The HRCT severity score (CT-SS) was moderately correlated with increased levels of periodontal parameters. CONCLUSIONS: Results of logistic regression analyses showed that the probability of developing severe COVID-19 was 2.81 times higher in patients with periodontitis. An association exists between periodontitis and severe COVID-19.