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Tendency in Pulmonary Aspergillosis Investigation during the COVID-19 Era: What Is Changing?
Caggiano, Giuseppina; Apollonio, Francesca; Consiglio, Mila; Gasparre, Valentina; Trerotoli, Paolo; Diella, Giusy; Lopuzzo, Marco; Triggiano, Francesco; Stolfa, Stefania; Mosca, Adriana; Montagna, Maria Teresa.
  • Caggiano G; Interdisciplinary Department of Medicine, Hygiene Section, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy.
  • Apollonio F; Interdisciplinary Department of Medicine, Hygiene Section, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy.
  • Consiglio M; Department of Biomedical Science and Human Oncology, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy.
  • Gasparre V; Department of Biomedical Science and Human Oncology, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy.
  • Trerotoli P; Interdisciplinary Department of Medicine, Hygiene Section, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy.
  • Diella G; Interdisciplinary Department of Medicine, Hygiene Section, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy.
  • Lopuzzo M; Department of Biomedical Science and Human Oncology, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy.
  • Triggiano F; Department of Biomedical Science and Human Oncology, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy.
  • Stolfa S; Interdisciplinary Department of Medicine, Hygiene Section, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy.
  • Mosca A; Interdisciplinary Department of Medicine, Hygiene Section, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy.
  • Montagna MT; Interdisciplinary Department of Medicine, Hygiene Section, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy.
Int J Environ Res Public Health ; 19(12)2022 06 09.
Article in English | MEDLINE | ID: covidwho-1884188
ABSTRACT
Aspergillosis is a disease caused by Aspergillus, and invasive pulmonary aspergillosis (IPA) is the most common invasive fungal infection leading to death in severely immuno-compromised patients. The literature reports Aspergillus co-infections in patients with COVID-19 (CAPA). Diagnosing CAPA clinically is complex since the symptoms are non-specific, and performing a bronchoscopy is difficult. Generally, the microbiological diagnosis of aspergillosis is based on cultural methods and on searching for the circulating antigens galactomannan and 1,3-ß-D-glucan in the bronchoalveolar lavage fluid (bGM) or serum (sGM). In this study, to verify whether the COVID-19 period has stimulated clinicians to pay greater attention to IPA in patients with respiratory tract infections, we evaluated the number of requests for GM-Ag research and the number of positive tests found during the pre-COVID-19 and COVID-19 periods. Our data show a significant upward trend in GM-Ag requests and positivity from the pre-COVID to COVID period, which is attributable in particular to the increase in IPA risk factors as a complication of COVID-19. In the COVID period, parallel to the increase in requests, the number of positive tests for GM-Ag also increased, going from 2.5% in the first period of 2020 to 12.3% in the first period of 2021.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Aspergillosis / Invasive Pulmonary Aspergillosis / COVID-19 Type of study: Diagnostic study / Risk factors Topics: Long Covid Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijerph19127079

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Aspergillosis / Invasive Pulmonary Aspergillosis / COVID-19 Type of study: Diagnostic study / Risk factors Topics: Long Covid Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijerph19127079