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Special Issue Editorial: "Infections, Inflammation and Neurodegeneration in Alzheimer Disease" Infections, Neuronal Senescence, and Dementia.
Licastro, Federico.
  • Licastro F; Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, 40126 Bologna, Italy.
Int J Mol Sci ; 23(11)2022 May 24.
Article in English | MEDLINE | ID: covidwho-1884204
ABSTRACT
Alzheimer's disease (AD) is a complex chronic disease of the brain characterized by several neurodegenerative mechanisms and is responsible for most dementia cases in the elderly. Declining immunity during ageing is often associated with peripheral chronic inflammation, and chronic neuroinflammation is a constant component of AD brain pathology. In the Special Issue published in 2021 eight papers were collected regarding different aspects of neurodegeneration associated with AD. Five papers presented and discussed infectious agents involved in brain AD pathology and three discussed data regarding receptors regulation and possible treatment of the disease. Below I will discuss and further elaborate on topics related to infections, inflammation, and neurodegenerative pathways in AD and brain senescence. The topic presented here may contribute to early intervention protocols for preventing or slowing the progression of cognitive deterioration in the elderly.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cognition Disorders / Alzheimer Disease Topics: Long Covid Limits: Aged / Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijms23115865

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cognition Disorders / Alzheimer Disease Topics: Long Covid Limits: Aged / Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijms23115865