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How to Restore Oxidative Balance That Was Disrupted by SARS-CoV-2 Infection.
Kielbowski, Kajetan; Herian, Mariola; Pawlik, Andrzej.
  • Kielbowski K; Department of Physiology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.
  • Herian M; Department of Physiology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.
  • Pawlik A; Department of Physiology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.
Int J Mol Sci ; 23(12)2022 Jun 07.
Article in English | MEDLINE | ID: covidwho-1884212
ABSTRACT
Coronavirus 2019 disease (COVID-19) is caused by different variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which emerged in December of 2019. COVID-19 pathogenesis is complex and involves a dysregulated renin angiotensin system. Severe courses of the disease are associated with a dysregulated immunological response known as cytokine storm. Many scientists have demonstrated that SARS-CoV-2 impacts oxidative homeostasis and stimulates the production of reactive oxygen species (ROS). In addition, the virus inhibits glutathione (GSH) and nuclear factor erythroid 2-related factor 2 (NRF2)-a major antioxidant which induces expression of protective proteins and prevents ROS damage. Furthermore, the virus stimulates NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasomes which play a significant role in inducing a cytokine storm. A variety of agents with antioxidant properties have shown beneficial effects in experimental and clinical studies of COVID-19. This review aims to present mechanisms of oxidative stress induced by SARS-CoV-2 and to discuss whether antioxidative drugs can counteract detrimental outcomes of a cytokine storm.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Topics: Variants Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijms23126377

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Topics: Variants Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijms23126377