Porcine Epidemic Diarrhea Virus Infection Induces Autophagosome Formation but Inhibits Autolysosome Formation during Replication.
Viruses
; 14(5)2022 05 15.
Article
in English
| MEDLINE | ID: covidwho-1884377
ABSTRACT
In this study, we investigated the correlation between the mechanism involved in porcine epidemic diarrhea virus (PEDV) replication and autophagic flux. In this study, we found that as PEDV replicated, production of LC3-II was significantly induced up to 24 h post-infection (hpi). Interestingly, although there was significant production of LC3-II, greater p62 accumulation was simultaneously found. Pretreatment with rapamycin significantly induced PEDV replication, but autolysosome formation was reduced. These results were confirmed by the evaluation of ATG5/ATG12 and LAMP1/LAMP2. Taken together, we conclude that PEDV infection induces autophagosome formation but inhibits autolysosome formation during replication.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Porcine epidemic diarrhea virus
/
Autophagosomes
Type of study:
Experimental Studies
Limits:
Animals
Language:
English
Year:
2022
Document Type:
Article
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