Neuroendocrine cancer of the prostate. Two case reports
Journal of Men's Health
; 18(3), 2022.
Article
in English
| EMBASE | ID: covidwho-1884949
ABSTRACT
Background:
Neuroendocrine cancer of the prostate can present in diverse clinical pictures, potentially hampering the diagnosis and probably leading to underdiagnosis.Methods:
Two cases are presented corresponding respectively to two forms of the disease de novo neuroendocrine cancer and dedifferenciation of an adenocarcinoma of the prostate to neuroendocrine cancer under long term luteinising hormone releasing hormone (LHRH) agonist treatment.Results:
Suspicion of neuroendocrine cancer may be raised in prostate cancer patients presenting either clinical or radiological metastatic progression without prostate specific antigen (PSA) rise, or relatively extended metastatic disease right at diagnosis associated to relatively low PSA, yet any non-pulmonary visceral metastases. Neuroendocrine cancer of the prostate can also turn out to be the origin of an adenocarcinoma of unknown primary.Conclusion:
In case these considerations are respected the risk of missing the correct diagnosis of a neuroendocrine cancer of the prostate may be minimised.
capecitabine; CD56 antigen; chromogranin A; cisplatin; cytokeratin 19; cytokeratin 20; cytokeratin 7; docetaxel; etoposide; gonadorelin agonist; homeobox protein Nkx 2.1; human serum albumin; neuron specific enolase; oxaliplatin; prostate specific antigen; synaptophysin; transcription factor Cdx2; transcription factor PAX8; tumor marker; abdominal radiography; adult; article; cancer combination chemotherapy; cancer diagnosis; cancer of unknown primary site; carcinogenesis; case report; cell dedifferentiation; clinical article; computer assisted tomography; coronavirus disease 2019; Gleason score; human; immunohistochemistry; liver metastasis; male; metastasis; middle aged; multiple cycle treatment; neuroendocrine prostate cancer; palliative chemotherapy; pelvis radiography; postoperative period; prostate adenocarcinoma; prostate cancer; prostatectomy; protein blood level; thorax radiography
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Case report
Language:
English
Journal:
Journal of Men's Health
Year:
2022
Document Type:
Article
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