Immunopathogenesis of multisystem inflammatory syndrome associated with COVID-19 in children

ABSTRACT

This review provides information about the role of the immune system in the development of multisystem inflammatory syndrome in children ( MIS - C ) associated with a new coronavirus infection ( COVID -19). The main clinical criteria for establishing the diagnosis are presented, the clinical picture and characteristics of biomarkers in MIS - C are described.. The main reason for the development of multisystem inflammatory syndrome, most researchers consider the activation of theimmune system with the development of a hyperergic inflammatory reaction. At the same time, the heterogeneity of MIS-C underlies various hypotheses of its development. The role of predisposing factors in the development of various variants of the immune response in MIS-C remains to be established, research is ongoing.