SARS-CoV-2 and sodium transport: a diabolical strategy
Revue Medicale Suisse
; 16(701):1450-1455, 2020.
Article
in French
| EMBASE | ID: covidwho-1885045
ABSTRACT
The Covid 19 pandemic remains a serious public health problem until effective drugs and/or vaccines are available. Can we explain why so many people remain asymptomatic but nevertheless highly contagious explaining the speed with which the pandemic has spread around the world? Can we explain why the acute respiratory distress syndrome (ARDS) appears late but can so quickly have a fatal outcome? In the lung, mucociliary clearance (CMC) and alveolar clearance (CA) depend on the transport of sodium through the plasma membrane of epithelial cells. This transport is mediated by a highly selective sodium channel (Epithelial Sodium Channel = ENaC) which could be a key element in the pulmonary pathophysiology of SARS-CoV-2 infection.
adult respiratory distress syndrome; article; cell membrane; coronavirus disease 2019; epithelium cell; fatality; human; human cell; lung diffusion; mucociliary clearance; nonhuman; pandemic; public health problem; Severe acute respiratory syndrome coronavirus 2; sodium transport; velocity; endogenous compound; epithelial sodium channel; sodium; vaccine
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
French
Journal:
Revue Medicale Suisse
Year:
2020
Document Type:
Article
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