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COVID-19 rapidly increases MDSCs and prolongs innate immune dysfunctions.
Schrijver, Irene T; Théroude, Charlotte; Antonakos, Nikolaos; Regina, Jean; Le Roy, Didier; Bart, Pierre-Alexandre; Chiche, Jean-Daniel; Perreau, Matthieu; Pantaleo, Giuseppe; Calandra, Thierry; Roger, Thierry.
  • Schrijver IT; Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Théroude C; Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Antonakos N; Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Regina J; Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Le Roy D; Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Bart PA; Service of Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Chiche JD; Service of Adult Intensive Care Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Perreau M; Service of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Pantaleo G; Service of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Calandra T; Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Roger T; Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Eur J Immunol ; 52(10): 1676-1679, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-1885394
ABSTRACT
We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that COVID-19 induces a rapid, transient upregulation of myeloid-derived suppressor cells (MDSCs) accompanied by a rapid, sustained (up to 3 months) hyporesponsiveness of dendritic cells and monocytes. Blood MDSCs may represent biomarkers and targets for intervention strategies in COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Myeloid-Derived Suppressor Cells / COVID-19 / Immune System Diseases Type of study: Prognostic study Limits: Humans Language: English Journal: Eur J Immunol Year: 2022 Document Type: Article Affiliation country: Eji.202249827

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Myeloid-Derived Suppressor Cells / COVID-19 / Immune System Diseases Type of study: Prognostic study Limits: Humans Language: English Journal: Eur J Immunol Year: 2022 Document Type: Article Affiliation country: Eji.202249827