Human cardiac organoids to model COVID-19 cytokine storm induced cardiac injuries.
J Tissue Eng Regen Med
; 16(9): 799-811, 2022 09.
Article
in English
| MEDLINE | ID: covidwho-1885455
ABSTRACT
Acute cardiac injuries occur in 20%-25% of hospitalized COVID-19 patients. Herein, we demonstrate that human cardiac organoids (hCOs) are a viable platform to model the cardiac injuries caused by COVID-19 hyperinflammation. As IL-1ß is an upstream cytokine and a core COVID-19 signature cytokine, it was used to stimulate hCOs to induce the release of a milieu of proinflammatory cytokines that mirror the profile of COVID-19 cytokine storm. The IL-1ß treated hCOs recapitulated transcriptomic, structural, and functional signatures of COVID-19 hearts. The comparison of IL-1ß treated hCOs with cardiac tissue from COVID-19 autopsies illustrated the critical roles of hyper-inflammation in COVID-19 cardiac insults and indicated the cardioprotective effects of endothelium. The IL-1ß treated hCOs thus provide a defined and robust model to assess the efficacy and potential side effects of immunomodulatory drugs, as well as the reversibility of COVID-19 cardiac injuries at baseline and simulated exercise conditions.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cytokine Release Syndrome
/
COVID-19
/
Heart Diseases
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
J Tissue Eng Regen Med
Journal subject:
Biotechnology
/
Histology
Year:
2022
Document Type:
Article
Affiliation country:
Term.3327
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