Your browser doesn't support javascript.
De novo Vogt-Koyanagi-Harada disease after vaccination for COVID-19, successfully treated with systemic steroid therapy and monitored with laser speckle flowgraphy.
Yamaguchi, Chiaki; Kunikata, Hiroshi; Hashimoto, Kazuki; Yoshida, Masaaki; Ninomiya, Takahiro; Hariya, Takehiro; Abe, Toshiaki; Nakazawa, Toru.
  • Yamaguchi C; Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Kunikata H; Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Hashimoto K; Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Yoshida M; Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Ninomiya T; Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Hariya T; Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Abe T; Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Nakazawa T; Division of Clinical Cell Therapy, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Am J Ophthalmol Case Rep ; 27: 101616, 2022 Sep.
Article in English | MEDLINE | ID: covidwho-1885588
ABSTRACT

Purpose:

Vogt-Koyanagi-Harada (VKH) disease after vaccination for coronavirus disease 2019 (COVID-19) is rare, and the prognosis for this condition and its effect on ocular blood flow remains unclear. The purpose of this paper is to present the first case of de novo VKH disease after the second vaccination for COVID-19 with an mRNA vaccine that was successfully treated with systemic steroid therapy and monitored with laser speckle flowgraphy (LSFG). Observations A 30s-year-old Japanese woman reported bilateral decreased visual function 2 weeks after receiving a second dose of the BNT162b2 mRNA vaccine. Best-corrected visual acuity was 20/50 OD and 20/70 OS. Optical coherence tomography revealed bilateral serous retinal detachment over the swollen choroidal layer. LFSG showed decreased blood flow in the peripapillary region of both eyes. This case was diagnosed as complete VKH syndrome, and the patient underwent systemic steroid therapy. After treatment, the retinal detachment disappeared, choroidal thickness decreased, and ocular blood flow increased. Three months later, visual acuity recovered to 20/20 in both eyes.

Conclusions:

Caution should be exercised in cases with visual symptoms after COVID-19 vaccination, even after more than one dose and more than one week after vaccination. LSFG may be a useful way to measure the ocular blood flow response to treatment and determine the prognosis for VKH disease after COVID-19 vaccination.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Observational study / Prognostic study Topics: Vaccines Language: English Journal: Am J Ophthalmol Case Rep Year: 2022 Document Type: Article Affiliation country: J.ajoc.2022.101616

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Observational study / Prognostic study Topics: Vaccines Language: English Journal: Am J Ophthalmol Case Rep Year: 2022 Document Type: Article Affiliation country: J.ajoc.2022.101616