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Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation.
Fernández-Castañeda, Anthony; Lu, Peiwen; Geraghty, Anna C; Song, Eric; Lee, Myoung-Hwa; Wood, Jamie; O'Dea, Michael R; Dutton, Selena; Shamardani, Kiarash; Nwangwu, Kamsi; Mancusi, Rebecca; Yalçin, Belgin; Taylor, Kathryn R; Acosta-Alvarez, Lehi; Malacon, Karen; Keough, Michael B; Ni, Lijun; Woo, Pamelyn J; Contreras-Esquivel, Daniel; Toland, Angus Martin Shaw; Gehlhausen, Jeff R; Klein, Jon; Takahashi, Takehiro; Silva, Julio; Israelow, Benjamin; Lucas, Carolina; Mao, Tianyang; Peña-Hernández, Mario A; Tabachnikova, Alexandra; Homer, Robert J; Tabacof, Laura; Tosto-Mancuso, Jenna; Breyman, Erica; Kontorovich, Amy; McCarthy, Dayna; Quezado, Martha; Vogel, Hannes; Hefti, Marco M; Perl, Daniel P; Liddelow, Shane; Folkerth, Rebecca; Putrino, David; Nath, Avindra; Iwasaki, Akiko; Monje, Michelle.
  • Fernández-Castañeda A; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
  • Lu P; Department of Immunobiology, Yale University, New Haven, CT, USA.
  • Geraghty AC; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
  • Song E; Department of Immunobiology, Yale University, New Haven, CT, USA.
  • Lee MH; National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
  • Wood J; Abilities Research Center, Department of Rehabilitation and Human Performance, Mount Sinai School of Medicine, New York, NY, USA.
  • O'Dea MR; Neuroscience Institute, NYU Grossman School of Medicine, New York, NY, USA.
  • Dutton S; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
  • Shamardani K; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
  • Nwangwu K; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
  • Mancusi R; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
  • Yalçin B; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
  • Taylor KR; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
  • Acosta-Alvarez L; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
  • Malacon K; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
  • Keough MB; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
  • Ni L; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
  • Woo PJ; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
  • Contreras-Esquivel D; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
  • Toland AMS; Department of Pathology, Stanford University, Stanford, CA, USA.
  • Gehlhausen JR; Department of Immunobiology, Yale University, New Haven, CT, USA.
  • Klein J; Department of Immunobiology, Yale University, New Haven, CT, USA.
  • Takahashi T; Department of Immunobiology, Yale University, New Haven, CT, USA.
  • Silva J; Department of Immunobiology, Yale University, New Haven, CT, USA.
  • Israelow B; Department of Immunobiology, Yale University, New Haven, CT, USA.
  • Lucas C; Department of Immunobiology, Yale University, New Haven, CT, USA.
  • Mao T; Department of Immunobiology, Yale University, New Haven, CT, USA.
  • Peña-Hernández MA; Department of Immunobiology, Yale University, New Haven, CT, USA.
  • Tabachnikova A; Department of Immunobiology, Yale University, New Haven, CT, USA.
  • Homer RJ; Department of Pathology, Yale University, New Haven, CT, USA.
  • Tabacof L; Abilities Research Center, Department of Rehabilitation and Human Performance, Mount Sinai School of Medicine, New York, NY, USA.
  • Tosto-Mancuso J; Abilities Research Center, Department of Rehabilitation and Human Performance, Mount Sinai School of Medicine, New York, NY, USA.
  • Breyman E; Abilities Research Center, Department of Rehabilitation and Human Performance, Mount Sinai School of Medicine, New York, NY, USA.
  • Kontorovich A; Cardiovascular Research Institute, Mount Sinai School of Medicine, New York, NY, USA.
  • McCarthy D; Abilities Research Center, Department of Rehabilitation and Human Performance, Mount Sinai School of Medicine, New York, NY, USA.
  • Quezado M; National Cancer Institute, Bethesda, MD, USA.
  • Vogel H; Department of Pathology, Stanford University, Stanford, CA, USA.
  • Hefti MM; Department of Pathology, University of Iowa, Iowa City, IA, USA.
  • Perl DP; Department of Pathology, Uniformed Services University of Health Sciences, Bethesda, MD, USA.
  • Liddelow S; Neuroscience Institute, NYU Grossman School of Medicine, New York, NY, USA; Departments of Neuroscience & Physiology and of Ophthalmology, NYU Grossman School of Medicine, New York, NY, USA; Parekh Center for Interdisciplinary Neurology, NYU Grossman School of Medicine, New York, NY, USA.
  • Folkerth R; Office of Chief Medical Examiner, New York, NY, USA.
  • Putrino D; Abilities Research Center, Department of Rehabilitation and Human Performance, Mount Sinai School of Medicine, New York, NY, USA.
  • Nath A; National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
  • Iwasaki A; Department of Immunobiology, Yale University, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University, New Haven, CT, USA. Electronic address: akiko.iwasaki@yale.edu.
  • Monje M; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA; Department of Pathology, Stanford University, Stanford, CA, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA. Electronic address: mmonje@stanford.edu.
Cell ; 185(14): 2452-2468.e16, 2022 07 07.
Article in English | MEDLINE | ID: covidwho-1885669
ABSTRACT
COVID survivors frequently experience lingering neurological symptoms that resemble cancer-therapy-related cognitive impairment, a syndrome for which white matter microglial reactivity and consequent neural dysregulation is central. Here, we explored the neurobiological effects of respiratory SARS-CoV-2 infection and found white-matter-selective microglial reactivity in mice and humans. Following mild respiratory COVID in mice, persistently impaired hippocampal neurogenesis, decreased oligodendrocytes, and myelin loss were evident together with elevated CSF cytokines/chemokines including CCL11. Systemic CCL11 administration specifically caused hippocampal microglial reactivity and impaired neurogenesis. Concordantly, humans with lasting cognitive symptoms post-COVID exhibit elevated CCL11 levels. Compared with SARS-CoV-2, mild respiratory influenza in mice caused similar patterns of white-matter-selective microglial reactivity, oligodendrocyte loss, impaired neurogenesis, and elevated CCL11 at early time points, but after influenza, only elevated CCL11 and hippocampal pathology persisted. These findings illustrate similar neuropathophysiology after cancer therapy and respiratory SARS-CoV-2 infection which may contribute to cognitive impairment following even mild COVID.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza, Human / COVID-19 / Neoplasms Type of study: Prognostic study Topics: Long Covid Limits: Animals / Humans Language: English Journal: Cell Year: 2022 Document Type: Article Affiliation country: J.cell.2022.06.008

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza, Human / COVID-19 / Neoplasms Type of study: Prognostic study Topics: Long Covid Limits: Animals / Humans Language: English Journal: Cell Year: 2022 Document Type: Article Affiliation country: J.cell.2022.06.008