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Predictors of mortality in patients with COVID-19 infection in different health-care settings: A retrospective analysis from a CORACLE study group.
Boglione, Lucio; Corcione, Silvia; Shbaklo, Nour; Lupia, Tommaso; Scabini, Silvia; Mornese Pinna, Simone; Borrè, Silvio; De Rosa, Francesco Giuseppe.
  • Boglione L; University of Eastern Piedmont, Department of Translational Medicine, Novara, Italy. Electronic address: lucio.boglione@uniupo.it.
  • Corcione S; Department of Medical Sciences, Infectious Diseases, University of Turin, Italy; Tufts University School of Medicine, Boston, MA, USA.
  • Shbaklo N; Department of Medical Sciences, Infectious Diseases, University of Turin, Italy.
  • Lupia T; Department of Medical Sciences, Infectious Diseases, University of Turin, Italy.
  • Scabini S; Department of Medical Sciences, Infectious Diseases, University of Turin, Italy.
  • Mornese Pinna S; Department of Medical Sciences, Infectious Diseases, University of Turin, Italy.
  • Borrè S; Saint Andrea Hospital, Unit of Infectious Diseases, Vercelli, Italy.
  • De Rosa FG; Department of Medical Sciences, Infectious Diseases, University of Turin, Italy.
Infect Dis Health ; 2022 Jun 14.
Article in English | MEDLINE | ID: covidwho-2228222
ABSTRACT

BACKGROUND:

Despite the large number of hospitalized patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, few data are available about risk factors and mortality in subjects with nosocomially acquired respiratory infection of Coronavirus Disease 2019 (COVID-19).

METHODS:

We retrospectively evaluated in a multicentric study -during the pre-vaccination era-all patients admitted with confirmed diagnosis of nosocomial COVID-19 (NC). Patients were classified according to provenance hospital-acquired NC or long-term care (LTC) facilities.

RESULTS:

Among overall 1047 patients evaluated with COVID-19, 137 had a confirmed diagnosis of NC (13%). 78 (56.9%) patients had hospital-acquired NC and 59 (43%) had LTC NC. Overall mortality was 35.8%, in hospital-acquired NC 24.4%, in LTC NC 50.8% (p < 0.001) (Log Rank test p = 0.001). Timing of diagnosis was significantly different between hospital acquired and LTC NC (3.5 vs 10 days, p < 0.001). In multivariate analysis age, intensive-care unit admission, LTC provenance and sepsis were significant predictors of mortality in patients with NC infection.

CONCLUSION:

Patients with NC are at higher risk of mortality (especially for LTC NC) and required preventive strategies, early diagnosis, and treatment to avoid COVID-19 cluster.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines Language: English Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines Language: English Year: 2022 Document Type: Article