Your browser doesn't support javascript.
Risk of vertical transmission of SARS CoV-2 infection to neonates born to covid positive mothers: A pilot study from a tertiary care hospital of North India.
Jha, Sangam; Singh, Akanksha; Anant, Monika; Bhadani, Poonam; Kant Chowdhary, Bhabesh; Mahto, Mala; Kumar Pati, Binod.
  • Jha S; Department of Obstetrics and Gynecology, AIIMS Patna, Bihar, India. Electronic address: sangam.jha78@gmail.com.
  • Singh A; Department of Obstetrics and Gynecology, AIIMS Patna, Bihar, India. Electronic address: akanksha7895@gmail.com.
  • Anant M; Department of Obstetrics and Gynecology, AIIMS Patna, Bihar, India. Electronic address: drmonikaa@aiimspatna.org.
  • Bhadani P; Department of Pathology, AIIMS Patna, Bihar, India. Electronic address: drpunamb@aiimspatna.org.
  • Kant Chowdhary B; Department of Neonatology, AIIMS Patna, Bihar, India. Electronic address: drbhaweshkant@gmail.com.
  • Mahto M; Department of Biochemistry, AIIMS Patna, Bihar, India. Electronic address: drmalam@aiimspatna.org.
  • Kumar Pati B; Department of Microbiology, AIIMS Patna, Bihar, India. Electronic address: drbinodkumarpati@aiimspatna.org.
J Infect Chemother ; 28(10): 1370-1374, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-1885918
ABSTRACT

OBJECTIVES:

To assess the risk of neonatal SARS-CoV-2 infection born to the women with confirmed SARS-CoV-2 infection. MATERIALS AND

METHODS:

This prospective study was conducted at single tertiary hospital from September 2020 and May 2021. 50 pregnant women with confirmed SARS-CoV-2 infection and 50 neonates were included for analysis. We performed comprehensive testing of all biological samples for vertical transmission including the cord blood immunoglobulin.

RESULTS:

We detected SARS-CoV-2 in one fetal membrane and one amniotic fluid sample. We also demonstrated presence of anti-SARS-CoV-2 IgM antibodies in cord blood of 3 neonates. Though none of the samples of vaginal secretion, breast milk and nasopharyngeal swab from neonates were tested positive for covid infection via RT-PCR. We demonstrated presence of anti-SARS-CoV-2 IgG antibodies in the cord blood which had shown positive correlation with increasing disease to delivery interval and disease severity.

CONCLUSION:

Vertical transmission of SARS-CoV-2 is possible. As virus was not detected in cervicovaginal secretions and breast milk so vertical transmission through this mechanism seems unlikely. Presence of IgG in cord blood is suggestive of passive immunity acquired from mother. This finding has greater clinical implication as large number of expecting mothers are being vaccinated.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: J Infect Chemother Journal subject: Microbiology / Drug Therapy Year: 2022 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: J Infect Chemother Journal subject: Microbiology / Drug Therapy Year: 2022 Document Type: Article