Bioactive prenylated phenolic compounds from the aerial parts of Glycyrrhiza uralensis.
Phytochemistry
; 201: 113284, 2022 Sep.
Article
in English
| MEDLINE | ID: covidwho-1886026
ABSTRACT
In this work, a bioassay-guided fractionation strategy was used to isolate 26 phenolic compounds from the ethyl acetate partition of an ethanol extract of the aerial parts of Glycyrrhiza uralensis Fisch. ex DC. Among them, 8 prenylated phenolic compounds (glycyuralins Q-X) were described for the first time. The two enantiomers of glycyuralin Q were purified and their absolute configurations were established by ECD spectral calculations. (1â³R, 2â³S)-glycyuralin Q and (1â³S, 2â³R)-glycyuralin Q showed significant inhibitory activities against SARS-CoV-2 virus proteases 3CLpro with IC50 values of 1.5 ± 1.0 and 4.0 ± 0.3 µM, and PLpro with IC50 values of 2.4 ± 0.2 and 1.9 ± 0.1 µM, respectively. Four compounds showed potent cytotoxic activities against A549, Huh-7, and HepG2 human cancer cells with IC50 values ranging from 0.5 to 2.5 µM.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Glycyrrhiza uralensis
/
COVID-19
/
Glycyrrhiza
Limits:
Humans
Language:
English
Journal:
Phytochemistry
Year:
2022
Document Type:
Article
Affiliation country:
J.phytochem.2022.113284
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