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Hamsters Protected from SARS-CoV-2 Delta Variant Challenge after Two Doses of Adjuvanted SARS-CoV-2 Recombinant Spike Protein (S-2P) and One Dose of Beta S-2P.
Kuo, Tsun-Yung; Lien, Chia En; Lin, Yi-Jiun; Lin, Meei-Yun; Wu, Chung-Chin; Tang, Wei-Hsuan; Campbell, John D; Traquina, Paula; Chuang, Ya-Shan; Liu, Luke Tzu-Chi; Cheng, Jinyi; Chen, Charles.
  • Kuo TY; Medigen Vaccine Biologics Corporation, Taipei City, Taiwan.
  • Lien CE; Department of Biotechnology and Animal Science, National Ilan University, Yilan County, Taiwan.
  • Lin YJ; Medigen Vaccine Biologics Corporation, Taipei City, Taiwan.
  • Lin MY; Institute of Public Health, National Yang-Ming Chiao Tung University, Taipei City, Taiwan.
  • Wu CC; Medigen Vaccine Biologics Corporation, Taipei City, Taiwan.
  • Tang WH; Medigen Vaccine Biologics Corporation, Taipei City, Taiwan.
  • Campbell JD; Medigen Vaccine Biologics Corporation, Taipei City, Taiwan.
  • Traquina P; Medigen Vaccine Biologics Corporation, Taipei City, Taiwan.
  • Chuang YS; Dynavax Technologies, Emeryville, California, USA.
  • Liu LT; Dynavax Technologies, Emeryville, California, USA.
  • Cheng J; Medigen Vaccine Biologics Corporation, Taipei City, Taiwan.
  • Chen C; Medigen Vaccine Biologics Corporation, Taipei City, Taiwan.
J Infect Dis ; 226(9): 1562-1567, 2022 Nov 01.
Article in English | MEDLINE | ID: covidwho-1886443
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern negatively impact the effectiveness of vaccines. In this study, we challenge hamsters with the delta variant after 2- or 3-dose inoculations with SARS-CoV-2 vaccines constructed from stabilized prefusion spike proteins (S-2P) of Wuhan (W) and beta (B) variants. Compared to 3 doses of W S-2P, 2 doses of W S-2P followed by a third dose of B S-2P induced the highest neutralizing antibody titer against live SARS-CoV-2 virus and enhanced neutralization of omicron variant pseudovirus. Reduced lung live virus titer and pathology suggested that all vaccination regimens protect hamsters from SARS-CoV-2 delta variant challenge.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / COVID-19 Vaccines / COVID-19 Topics: Vaccines / Variants Limits: Animals Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / COVID-19 Vaccines / COVID-19 Topics: Vaccines / Variants Limits: Animals Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis