KIDNEY TRANSPLANTATION WITH COVID-19 POSITIVE DONORS: A SERIES OF 55 CASES
Journal of Urology
; 207(SUPPL 5):e596, 2022.
Article
in English
| EMBASE | ID: covidwho-1886517
ABSTRACT
INTRODUCTION AND OBJECTIVE:
Organs from deceaseddonors who tested positive for COVID-19 were thought to be ineligible for transplantation. Despite lack of evidence showing that COVID-19 can be transmitted through urine or blood. We began to transplant kidneys from COVID-positive deceased-donors in February 2021 and this report comprises our early outcomes in this patient cohort.METHODS:
From Feb 2021 to Oct 2021, 55 patients underwent kidney transplantation from 34 COVID-19 positive donors. Prior to initiating this clinical practice, formalized selection criteria for organs from COVID-19 positive deceased-donors were adopted by transplant surgeons, transplant nephrologists, and infectious disease physicians. If a deceased-donor suited these pre-determined criteria, individual kidney selection followed our usual programmatic criteria.RESULTS:
The mean donor age was 34±13.7 years with a mean kidney donor profile index (KDPI) of 36.9±22.7%. All donors had at least 1 positive COVID-19 test from the nasopharyngeal ribonucleic acid swab test within a median of 4 (0-76) days prior to declaration as a deceased-donor. Extracorporeal membrane oxygenation (ECMO) was used in 6 donors. The initial and terminal mean creatinine was 1.1±1.1 mg/dl and 1.0±0.4 mg/dL. This patient cohort includes 36 male recipients and 19 female recipients. Mean age among all recipients was 51.2±13.5 years. Thirty-seven recipients (66.7%) were dialysis dependent. A similar proportion (67.3%) had received both COVID-19 vaccine doses. Delayed graft function occurred in 19.6% of the recipients. No patient tested positive for COVID-19 after surgery. At a mean follow up duration of 3.5 months, all kidney allografts are functioning, with a mean serum creatinine of 1.6±0.7 mg/dl. One patient underwent allograft nephrectomy at 1.5 months post-transplant due to Pseudomonas aeruginosa vascular infection.CONCLUSIONS:
Transplantation of kidneys from COVID-19 positive donors is safe. Outcomes are comparable to kidneys from regular donors.
creatinine; RNA; SARS-CoV-2 vaccine; adult; clinical practice; cohort analysis; communicable disease; conference abstract; controlled study; coronavirus disease 2019; COVID-19 testing; creatinine blood level; deceased donor; delayed graft function; dialysis; extracorporeal oxygenation; female; follow up; human; human tissue; kidney allograft; kidney donor; kidney transplantation; major clinical study; male; middle aged; nephrectomy; nephrologist; nonhuman; physician; Pseudomonas aeruginosa; surgery; transplant surgeon
Full text:
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Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Journal of Urology
Year:
2022
Document Type:
Article
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