Fever following Covid-19 vaccination in subjects with Brugada syndrome: Incidence and management.
J Cardiovasc Electrophysiol
; 33(8): 1874-1879, 2022 08.
Article
in English
| MEDLINE | ID: covidwho-1886683
ABSTRACT
BACKGROUND:
Fever is a potential side effect of the Covid-19 vaccination. Patients with Brugada syndrome (BrS) have an increased risk of life-threatening arrhythmias when experiencing fever. Prompt treatment with antipyretic drugs is suggested in these patients. AIM OF THE STUDY To evaluate the incidence and management of fever within 48 h from Covid-19 vaccination among BrS patients.METHODS:
One hundred sixty-three consecutive patients were enrolled in a prospective registry involving five European hospitals with a dedicated inherited disease ambulatory.RESULTS:
The mean age was 50 ± 14 years and 121 (75%) patients were male. Prevalence of Brugada electrocardiogram (ECG) pattern type-1, -2, and -3 was 32%, 44%, and 24%, respectively. Twenty-eight (17%) patients had an implantable cardioverter-defibrillator (ICD). Fever occurred in 32 (19%) BrS patients after 16 ± 10 h from vaccination, with a peak of body temperature of 37.9° ± 0.5°. Patients with fever were younger (39 ± 13 vs. 48 ± 13 years, p = .04). No additional differences in terms of sex and cardiovascular risk factors were found between patients with fever and not. Twenty-seven (84%) out of 32 patients experienced mild fever and five (16%) moderate fever. Pharmacological treatment with antipyretic drugs was required in 18 (56%) out of 32 patients and was associated with the resolution of symptoms. No patient required hospital admission and no arrhythmic episode was recorded in patients with ICD within 48 h after vaccination. No induced type 1 BrS ECG pattern and new ECG features were found among patients with moderate fever.CONCLUSION:
Fever is a common side effect in BrS patients after the Covid-19 vaccination. Careful evaluation of body temperature and prompt treatment with antipyretic drugs may be needed.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Defibrillators, Implantable
/
Brugada Syndrome
/
Antipyretics
/
COVID-19 Vaccines
/
COVID-19
Type of study:
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Vaccines
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
J Cardiovasc Electrophysiol
Journal subject:
Vascular Diseases
/
Cardiology
/
Physiology
Year:
2022
Document Type:
Article
Affiliation country:
Jce.15596
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