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Clinical Characteristics and Predictors of Mortality in Elderly Patients Hospitalized with COVID-19 in Bangladesh: A Multicenter, Retrospective Study.
Asaduzzaman, Md; Nazmul Alam, Z H M; Zabed Jillul Bari, Mohammad; Jahangir Alam, M M; Ranjan Chakraborty, Shishir; Ferdousi, Tasnim.
  • Asaduzzaman M; Department of Medicine, Sylhet MAG Osmani Medical College Hospital, Sylhet 3100, Bangladesh.
  • Nazmul Alam ZHM; Department of Medicine, Sylhet MAG Osmani Medical College Hospital, Sylhet 3100, Bangladesh.
  • Zabed Jillul Bari M; Department of Medicine, Sylhet MAG Osmani Medical College, Sylhet 3100, Bangladesh.
  • Jahangir Alam MM; Department of Medicine, Sylhet MAG Osmani Medical College, Sylhet 3100, Bangladesh.
  • Ranjan Chakraborty S; Department of Medicine, Sylhet MAG Osmani Medical College, Sylhet 3100, Bangladesh.
  • Ferdousi T; Department of Ophthalmology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Interdiscip Perspect Infect Dis ; 2022: 5904332, 2022.
Article in English | MEDLINE | ID: covidwho-2250317
ABSTRACT

Purpose:

Elderly patients are at high risk of fatality from COVID-19. The present work aims to describe the clinical characteristics of elderly inpatients with COVID-19 and identify the predictors of in-hospital mortality at admission. Materials and

Methods:

In this retrospective, multicenter cohort study, we included elderly COVID-19 inpatients (n = 245) from four hospitals in Sylhet, Bangladesh, who had been discharged between October 2020 and February 2021. Demographic, clinical, and laboratory data were extracted from hospital records and compared between survivors and nonsurvivors. We used univariable and multivariable logistic regression analysis to explore the risk factors associated with in-hospital death. Principal Results. Of the included patients, 202 (82.44%) were discharged and 43 (17.55%) died in hospital. Except hypertension, other comorbidities like diabetes, chronic kidney disease, ischemic heart disease, and chronic obstructive pulmonary disease were more prevalent in nonsurvivors. Nonsurvivors had a higher prevalence of leukocytosis (51.2 versus 30.7; p=0.01), lymphopenia (72.1 versus 55; p=0.05), and thrombocytopenia (20.9 versus 9.9; p=0.07). Multivariable regression analysis showed an increasing odds ratio of in-hospital death associated with older age (odds ratio 1.05, 95% CI 1.01-1.10, per year increase; p=0.009), thrombocytopenia (OR = 3.56; 95% CI 1.22-10.33, p=0.019), and admission SpO2 (OR 0.91, 95% CI 0.88-0.95; p=0.001).

Conclusions:

Higher age, thrombocytopenia, and lower initial level of SpO2 at admission are predictors of in-hospital mortality in elderly patients with COVID-19.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal: Interdiscip Perspect Infect Dis Year: 2022 Document Type: Article Affiliation country: 2022

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal: Interdiscip Perspect Infect Dis Year: 2022 Document Type: Article Affiliation country: 2022