Efficacy and safety of corticosteroid regimens for the treatment of hospitalized COVID-19 patients: a meta-analysis.
Future Virol
; 17(7): 463-489, 2022 Jul.
Article
in English
| MEDLINE | ID: covidwho-1887073
ABSTRACT
Aim:
To evaluate the efficacy and safety of corticosteroids for treating hospitalized COVID-19 patients. Materials &methods:
Efficacy outcomes included time to negative SARS-CoV-2 tests, length of stay, duration and incidence of intensive unit care stay, incidence of mortality and duration and incidence of mechanical ventilation. Safety outcomes included the incidence of adverse events and severe adverse events, incidence of hyperglycemia and incidence of nosocomial infections.Results:
Ninety-five randomized controlled trials (RCTs) and observational studies (n = 42,205) were included. Corticosteroids were associated with increased length of stay (based on RCT only), increased time to negative tests, decreased length of mechanical ventilation and increased odds of hyperglycemia.Conclusion:
Corticosteroids should be considered in patients requiring mechanical ventilation, and glycemic monitoring may be needed when administering corticosteroids.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
/
Reviews
Language:
English
Journal:
Future Virol
Year:
2022
Document Type:
Article
Affiliation country:
Fvl-2021-0244
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