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Mapping of SARS-CoV-2 spike protein evolution during first and second waves of COVID-19 infections in India.
Rajpal, Vijay Rani; Sharma, Shashi; Kumar, Avinash; Vaishnavi, Samantha; Singh, Apekshita; Sehgal, Deepmala; Tiwari, Mughdha; Goel, Shailendra; Raina, Soom Nath.
  • Rajpal VR; Department of Botany, Hansraj College, University of Delhi, Delhi, 110007, India.
  • Sharma S; Virology Division, Defence Research & Development Establishment, Gwalior, Madhya Pradesh, 474002, India.
  • Kumar A; Department of Botany, Vinoba Bhave University, Hazaribag, Jharkhand, 825319, India.
  • Vaishnavi S; Department of Botany, Central University of Jammu, Rahya Suchani (Bagla), Distt. Samba, Jammu and Kashmir, 181143, India.
  • Singh A; Amity Institute of Biotechnology, Amity University Uttar Pradesh, Sector 125, Noida, Uttar Pradesh, 201313, India.
  • Sehgal D; International Maize & Wheat Improvement Center (CIMMYT) Carretera México-Veracruz Km. 45, El Batán, Texcoco, 56237, México.
  • Tiwari M; ICMR-National Institute of Occupational Health (ICMR-NIOH), Meghaninagar, Ahmedabad, Gujarat, 380016, India.
  • Goel S; Department of Botany, University of Delhi, Delhi, 110007, India.
  • Raina SN; Amity Institute of Biotechnology, Amity University Uttar Pradesh, Sector 125, Noida, Uttar Pradesh, 201313, India.
Future Virol ; 2022 May.
Article in English | MEDLINE | ID: covidwho-1887075
ABSTRACT

Aim:

The aim of this study was to investigate the SARS-CoV-2 spike protein evolution during the first and second wave of COVID-19 infections in India. Materials &

Methods:

Detailed mutation analysis was done in 763 samples taken from GISAID for the ten most affected Indian states between March 2020 to August 2021.

Results:

The study revealed 242 mutations corresponding to 207 sites. Fifty one novel mutations emerged during the assessment period, including many with higher transmissibility and immune evasion functions. Highest number of mutations per spike protein also rose from 5 (first wave) to 13 (second wave).

Conclusion:

The study identified mutation-rich and no mutation regions in the spike protein. The conserved spike regions can be useful for designing future diagnostics, vaccines and therapeutics.
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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Fvl-2021-0267

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Fvl-2021-0267