Correlation between Multidrug Resistance Infection with Clinical Outcomes of Critically ill Patients with COVID-19 Admitted to an Intensive Care at RSUP Dr. M. Djamil in Indonesia

ABSTRACT

BACKGROUND: Approximately 14–50% of severe COVID-19 patients are admitted to the Intensive Care Unit (ICU) that acquires a multidrug-resistant bacterial infection (MDR) and worsens clinical outcomes of patients. AIM: We aim to determine the increased risk of MDR infection in the ICU including large-spectrum antibiotic administration, invasive procedure performance (mechanical ventilation), and clinical outcomes of patient. METHODS: We analyzed 227 patients with a primary diagnosis of COVID-19 on mechanical ventilation who were admitted to ICU COVID-19 RSUP Dr. M. Djamil from 2020 to 2021. Demographic information, sputum culture results, intubation, and clinical outcomes were all collected in the medical records for this retrospective cohort study. Patients who were hospitalized for <48 h in the ICU were excluded from the study. An independent t-test and a Chi-square test were used to analyze the data. RESULTS: In sixty patients (26.4%), bacteria were found in the sputum culture, 40 patients (66.7%) of them were MDR. The most common bacteria found was Acinetobacter baumanii (35%) followed by Klebsiella pneumonia (21.7%). There is a significant relationship between MDR (p-value 0.000) and intubation (p-value, 000) to clinical outcomes of patients (improvement or death). There is a significant relationship between intubation and MDR (p-value 0.009). CONCLUSION: MDR patient status affected the outcomes of COVID-19 patients in the ICU. Patients with MDR were more likely to have a poor clinical outcome.