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New insights on malaria.
Castelli, Francesco; Tomasoni, Lina R..
  • Castelli F; rofessor of Infectious Diseases and UNESCO Chairholder "Training and empowering human resources for health development in resource-limited countries", University of Brescia, Italy
  • Tomasoni LR; Division of Infectious and Tropical Diseases, ASST Spedali Civili di Brescia, Italy
New Microbiol ; 45(2): 83-98, 2022 04.
Article in English | MEDLINE | ID: covidwho-1887519
ABSTRACT
Malaria is long known as a deadly vector borne infection, caused by five parasite species of the coccidian genus Plasmodia that are present in as many as 85 countries. Despite significant progresses have been achieved to control the infection by early diagnosis and artemisinin combination treatment, insecticide-treated nets and indoor residual spraying, malaria still represents a major public health issue in many endemic low-income countries. New diagnostic tools of higher sensitivity and specificity are now available for use in endemic countries to better guide diagnosis and treatment. In particular, highly sensitive rapid antigenic tests are now available and the loop-mediated isothermal amplification is a very promising and highly sensitive diagnostic tool. After 2015, decreasing morbidity and mortality trends have been stagnating because of limited funding, emergence of parasite and vector resistance to drugs and insecticides respectively and, recently, by the disrupting effect of COVID-19 pandemic. The incomplete knowledge of the complex immunity of malaria infection has slowed the development of an effective vaccine. However, in 2021, the RTS-S vaccine, however of suboptimal protective efficacy, has been made available for routine use in children above 5 months of age. Population movements has increased the chance of observing imported malaria in non-endemic areas, where malaria competent vectors may still exist.
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Collection: International databases Database: MEDLINE Main subject: COVID-19 / Insecticides / Malaria Type of study: Diagnostic study / Observational study Topics: Long Covid / Vaccines Limits: Child / Humans Language: English Journal: New Microbiol Journal subject: Microbiology Year: 2022 Document Type: Article Affiliation country: Italy

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Collection: International databases Database: MEDLINE Main subject: COVID-19 / Insecticides / Malaria Type of study: Diagnostic study / Observational study Topics: Long Covid / Vaccines Limits: Child / Humans Language: English Journal: New Microbiol Journal subject: Microbiology Year: 2022 Document Type: Article Affiliation country: Italy