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PI3K/Akt/mTOR pathway: a potential target for anti-SARS-CoV-2 therapy.
Fattahi, Soheila; Khalifehzadeh-Esfahani, Zahra; Mohammad-Rezaei, Mina; Mafi, Sahar; Jafarinia, Morteza.
  • Fattahi S; Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
  • Khalifehzadeh-Esfahani Z; Immunology Department, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Mohammad-Rezaei M; Immunology Research Center, Iran University of Medical Sciences, Tehran, Iran.
  • Mafi S; Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Jafarinia M; Medical Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
Immunol Res ; 70(3): 269-275, 2022 06.
Article in English | MEDLINE | ID: covidwho-1889039
ABSTRACT
Coronavirus disease 2019 (COVID-19) is a viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A single-stranded RNA virus from a ß-Coronaviridae family causes acute clinical manifestations. Its high death rate and severe clinical symptoms have turned it into the most significant challenge worldwide. Up until now, several effective COVID-19 vaccines have been designed and marketed, but our data on specialized therapeutic drugs for the treatment of COVID-19 is still limited. In order to synthesis virus particles, SARS-CoV-2 uses host metabolic pathways such as phosphoinositide3-kinase (PI3K)/protein kinase B (PKB, also known as AKT)/mammalian target of rapamycin (mTOR). mTOR is involved in multiple biological processes. Over-activation of the mTOR pathway improves viral replication, which makes it a possible target in COVID-19 therapy. Clinical data shows the hyperactivation of the mTOR pathway in lung tissues during respiratory viral infections. However, the exact impact of mTOR pathway inhibitors on the COVID-19 severity and death rate is yet to be thoroughly investigated. There are several mTOR pathway inhibitors. Rapamycin is the most famous inhibitor of mTORC1 among all. Studies on other respiratory viruses suggest that the therapeutic inhibitors of the mTOR pathway, especially rapamycin, can be a potential approach to anti-SARS-CoV-2 therapy. Using therapeutic methods that inhibit harmful immune responses can open a new chapter in treating severe COVID-19 disease. We highlighted the potential contribution of PI3K/Akt/mTOR inhibitors in the treatment of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Immunol Res Journal subject: Allergy and Immunology Year: 2022 Document Type: Article Affiliation country: S12026-022-09268-x

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Immunol Res Journal subject: Allergy and Immunology Year: 2022 Document Type: Article Affiliation country: S12026-022-09268-x