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Genetic diversity of SARS-CoV-2 infections in Ghana from 2020-2021.
Morang'a, Collins M; Ngoi, Joyce M; Gyamfi, Jones; Amuzu, Dominic S Y; Nuertey, Benjamin D; Soglo, Philip M; Appiah, Vincent; Asante, Ivy A; Owusu-Oduro, Paul; Armoo, Samuel; Adu-Gyasi, Dennis; Amoako, Nicholas; Oliver-Commey, Joseph; Owusu, Michael; Sylverken, Augustina; Fenteng, Edward D; M'cormack, Violette V; Tei-Maya, Frederick; Quansah, Evelyn B; Ayivor-Djanie, Reuben; Amoako, Enock K; Ogbe, Isaac T; Yemi, Bright K; Osei-Wusu, Israel; Mettle, Deborah N A; Saiid, Samirah; Tapela, Kesego; Dzabeng, Francis; Magnussen, Vanessa; Quaye, Jerry; Opurum, Precious C; Carr, Rosina A; Ababio, Patrick T; Abass, Abdul-Karim; Akoriyea, Samuel K; Amoako, Emmanuella; Kumi-Ansah, Frederick; Boakye, Oliver D; Mibut, Dam K; Odoom, Theophilus; Ofori-Boadu, Lawrence; Allegye-Cudjoe, Emmanuel; Dassah, Sylvester; Asoala, Victor; Asante, Kwaku P; Phillips, Richard O; Osei-Atweneboana, Mike Y; Gyapong, John O; Kuma-Aboagye, Patrick; Ampofo, William K.
  • Morang'a CM; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
  • Ngoi JM; Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
  • Gyamfi J; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
  • Amuzu DSY; Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
  • Nuertey BD; University of Health and Allied Sciences COVID-19 Testing and Research Centre, Ho, Ghana.
  • Soglo PM; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
  • Appiah V; Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
  • Asante IA; Tamale Teaching Hospital Intensive Care Unit, Ghana Health Service, Tamale, Ghana.
  • Owusu-Oduro P; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
  • Armoo S; Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
  • Adu-Gyasi D; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
  • Amoako N; Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
  • Oliver-Commey J; Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana.
  • Owusu M; LEDing Medical Laboratory, Accra, Ghana.
  • Sylverken A; Biomedical and Public Health Research Unit, Council for Scientific and Industrial Research, Accra, Ghana.
  • Fenteng ED; Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana.
  • M'cormack VV; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
  • Tei-Maya F; Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana.
  • Quansah EB; Ghana Infectious Disease Centre, Accra, Ghana.
  • Ayivor-Djanie R; Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
  • Amoako EK; Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
  • Ogbe IT; Accra Veterinary Laboratory, Veterinary Services Directorate, Accra, Ghana.
  • Yemi BK; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
  • Osei-Wusu I; Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
  • Mettle DNA; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
  • Saiid S; Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
  • Tapela K; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
  • Dzabeng F; Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
  • Magnussen V; University of Health and Allied Sciences COVID-19 Testing and Research Centre, Ho, Ghana.
  • Quaye J; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
  • Opurum PC; Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
  • Carr RA; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
  • Ababio PT; Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
  • Abass AK; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
  • Akoriyea SK; Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
  • Amoako E; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
  • Kumi-Ansah F; Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
  • Boakye OD; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
  • Mibut DK; Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
  • Odoom T; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
  • Ofori-Boadu L; Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
  • Allegye-Cudjoe E; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
  • Dassah S; Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
  • Asoala V; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
  • Asante KP; Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
  • Phillips RO; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
  • Osei-Atweneboana MY; Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
  • Gyapong JO; Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana.
  • Kuma-Aboagye P; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
  • Ampofo WK; Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
Nat Commun ; 13(1): 2494, 2022 05 06.
Article in English | MEDLINE | ID: covidwho-1890179
ABSTRACT
The COVID-19 pandemic is one of the fastest evolving pandemics in recent history. As such, the SARS-CoV-2 viral evolution needs to be continuously tracked. This study sequenced 1123 SARS-CoV-2 genomes from patient isolates (121 from arriving travellers and 1002 from communities) to track the molecular evolution and spatio-temporal dynamics of the SARS-CoV-2 variants in Ghana. The data show that initial local transmission was dominated by B.1.1 lineage, but the second wave was overwhelmingly driven by the Alpha variant. Subsequently, an unheralded variant under monitoring, B.1.1.318, dominated transmission from April to June 2021 before being displaced by Delta variants, which were introduced into community transmission in May 2021. Mutational analysis indicated that variants that took hold in Ghana harboured transmission enhancing and immune escape spike substitutions. The observed rapid viral evolution demonstrates the potential for emergence of novel variants with greater mutational fitness as observed in other parts of the world.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Variants Limits: Humans Country/Region as subject: Africa Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-30219-5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Variants Limits: Humans Country/Region as subject: Africa Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-30219-5