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Potential protective effect against SARS-CoV-2 infection by APOE rs7412 polymorphism.
Espinosa-Salinas, Isabel; Colmenarejo, Gonzalo; Fernández-Díaz, Cristina M; Gómez de Cedrón, Marta; Martinez, J Alfredo; Reglero, Guillermo; Ramírez de Molina, Ana.
  • Espinosa-Salinas I; IMDEA-Food Institute, CEI UAM+CSIC, 28049, Madrid, Spain. mariaisabel.espinosa@imdea.org.
  • Colmenarejo G; IMDEA-Food Institute, CEI UAM+CSIC, 28049, Madrid, Spain.
  • Fernández-Díaz CM; IMDEA-Food Institute, CEI UAM+CSIC, 28049, Madrid, Spain.
  • Gómez de Cedrón M; IMDEA-Food Institute, CEI UAM+CSIC, 28049, Madrid, Spain.
  • Martinez JA; IMDEA-Food Institute, CEI UAM+CSIC, 28049, Madrid, Spain.
  • Reglero G; Center for Nutrition Research (CIN), Navarra Institute for Health Research (IdiSNA), 31008, Pamplona, Spain.
  • Ramírez de Molina A; Center of Biomedical Research in Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, 28029, Madrid, Spain.
Sci Rep ; 12(1): 7247, 2022 05 04.
Article in English | MEDLINE | ID: covidwho-1890239
ABSTRACT
The pandemic burden caused by the SARS-CoV-2 coronavirus constitutes a global public health emergency. Increasing understanding about predisposing factors to infection and severity is now a priority. Genetic, metabolic, and environmental factors can play a crucial role in the course and clinical outcome of COVID-19. We aimed to investigate the putative relationship between genetic factors associated to obesity, metabolism and lifestyle, and the presence and severity of SARS-CoV-2 infection. A total of 249 volunteers (178 women and 71 men, with mean and ± SD age of 49 ± 11 years) characterized for dietary, lifestyle habits and anthropometry, were studied for presence and severity of COVID-19 infection, and genotyped for 26 genetic variants related to obesity, lipid profile, inflammation, and biorhythm patterns. A statistically significant association was found concerning a protective effect of APOE rs7412 against SARS-CoV-2 infection (p = 0.039; OR 0.216; CI 0.084, 0.557) after correction for multiple comparisons. This protective effect was also ascribed to the APOɛ2 allele (p = 0.001; OR 0.207; CI 0.0796, 0.538). The genetic variant rs7412 resulting in ApoE2, genetic determinant of lipid and lipoprotein levels, could play a significant role protecting against SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Apolipoproteins E / COVID-19 Type of study: Etiology study / Experimental Studies / Prognostic study Topics: Variants Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-10923-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Apolipoproteins E / COVID-19 Type of study: Etiology study / Experimental Studies / Prognostic study Topics: Variants Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-10923-4