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Conditionally designed luminescent DNA crystals doped by Ln3+(Eu3+/Tb3+) complexes or fluorescent proteins with smart drug sensing property.
Xiu, Dan; Zhao, Sibo; Li, Zhenhua; Xu, Yanan; Wang, Yao; Zhu, Zhijun; Zhang, Min; Snow, Christopher D; Belfiore, Laurence A; Tang, Jianguo.
  • Xiu D; Institute of Hybrid Materials, National Center of International Research for Hybrid Materials Technology, National Base of International Science & Technology Cooperation, College of Materials Science and Engineering, Qingdao University, Qingdao, 266071, P. R. China. tang@qdu.edu.cn.
  • Zhao S; Institute of Hybrid Materials, National Center of International Research for Hybrid Materials Technology, National Base of International Science & Technology Cooperation, College of Materials Science and Engineering, Qingdao University, Qingdao, 266071, P. R. China. tang@qdu.edu.cn.
  • Li Z; Institute of Hybrid Materials, National Center of International Research for Hybrid Materials Technology, National Base of International Science & Technology Cooperation, College of Materials Science and Engineering, Qingdao University, Qingdao, 266071, P. R. China. tang@qdu.edu.cn.
  • Xu Y; Institute of Hybrid Materials, National Center of International Research for Hybrid Materials Technology, National Base of International Science & Technology Cooperation, College of Materials Science and Engineering, Qingdao University, Qingdao, 266071, P. R. China. tang@qdu.edu.cn.
  • Wang Y; Institute of Hybrid Materials, National Center of International Research for Hybrid Materials Technology, National Base of International Science & Technology Cooperation, College of Materials Science and Engineering, Qingdao University, Qingdao, 266071, P. R. China. tang@qdu.edu.cn.
  • Zhu Z; Institute of Hybrid Materials, National Center of International Research for Hybrid Materials Technology, National Base of International Science & Technology Cooperation, College of Materials Science and Engineering, Qingdao University, Qingdao, 266071, P. R. China. tang@qdu.edu.cn.
  • Zhang M; Institute of Hybrid Materials, National Center of International Research for Hybrid Materials Technology, National Base of International Science & Technology Cooperation, College of Materials Science and Engineering, Qingdao University, Qingdao, 266071, P. R. China. tang@qdu.edu.cn.
  • Snow CD; Department of Chemical and Biological Engineering, Colorado State University, Fort Collins, Colorado, 80523, USA. Christopher.Snow@colostate.edu.
  • Belfiore LA; Institute of Hybrid Materials, National Center of International Research for Hybrid Materials Technology, National Base of International Science & Technology Cooperation, College of Materials Science and Engineering, Qingdao University, Qingdao, 266071, P. R. China. tang@qdu.edu.cn.
  • Tang J; Department of Chemical and Biological Engineering, Colorado State University, Fort Collins, Colorado, 80523, USA. Christopher.Snow@colostate.edu.
J Mater Chem B ; 10(34): 6443-6452, 2022 08 31.
Article in English | MEDLINE | ID: covidwho-1890296
ABSTRACT
In this work, a designed porous DNA crystal with high intrinsic biocompatibility was used as the scaffold material to load fluorescent guest molecules to detect anti-cancer drugs. It is shown here that the synthesized crystals have the characteristics consistent with the designed large solvent channels, and can therefore accommodate guest molecules such as fluorescent proteins that cannot be accommodated by less porous crystals. Eu(TTA)3phen and Tb(acac)3phen lanthanide complexes were individually noncovalently loaded into the porous crystals, resulting in hybrid luminescent DNA crystals. Emodin, an anti-cancer, anti-tumor, anti-inflammatory drug, was found to quench lanthanide complexes in solution or in crystals. Notably, emodin is the active ingredient of Lianhua Qingwen Capsule, an anti-COVID-19 drug candidate. Therefore, the porous DNA crystals reported here have potential applications as a biocompatible and theranostic delivery biomaterial for functional macromolecules.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Emodin / Lanthanoid Series Elements Language: English Journal: J Mater Chem B Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Emodin / Lanthanoid Series Elements Language: English Journal: J Mater Chem B Year: 2022 Document Type: Article