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A close shave: How SARS-CoV-2 induces the loss of cilia.
Fonseca, Barbara F; Chakrabarti, Lisa A.
  • Fonseca BF; Control of Chronic Viral Infections Group, Virus and Immunity Unit, Institut Pasteur, Université Paris Cité, CNRS UMR 3569, Paris, France.
  • Chakrabarti LA; Biomaterials and Microfluidics Core Facility, Institut Pasteur, Paris, France.
J Cell Biol ; 221(7)2022 07 04.
Article in English | MEDLINE | ID: covidwho-1890797
ABSTRACT
Wang et al. report in this issue (2022. J. Cell Biol.https//doi.org/10.1083/jcb.202108015) that the SARS-CoV-2 protein ORF10 increases the activity of the E3 ligase CUL2ZYG11B, leading to the degradation of multiple ciliary proteins. The resulting loss of cilia may facilitate the spread of SARS-CoV-2 in the respiratory tree.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cilia / Ubiquitin-Protein Ligases / COVID-19 Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Jcb.202206023

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cilia / Ubiquitin-Protein Ligases / COVID-19 Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Jcb.202206023