Role of integrin avbeta1 for porcine epidemic diarrhea virus (PEDV) infection in Vero cells

ABSTRACT

In this study, we detected the viral load and protein expression of porcine epidemic diarrhea virus (PEDV) after overexpression and inhibition of integrin avbeta1 on the surface of Vero cells, and then cleared the role of integrin avbeta1 in the PEDV infection process. The results showed that the viral load and protein expression were significantly increased in the Vero cells which overexpressed integrin avbeta1, and the viral load and protein expression were significantly reduced in the Vero cells with silent integrin avbeta1 gene. Integrin avbeta1 promotes PEDV to infect Vero cells.