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Predictors of COVID-19 severity among pregnant patients.
Januszewski, Marcin; Ziuzia-Januszewska, Laura; Jakimiuk, Alicja A; Oleksik, Tomasz; Pokulniewicz, Marek; Wierzba, Waldemar; Kozlowski, Krzysztof; Jakimiuk, Artur J.
  • Januszewski M; Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland.
  • Ziuzia-Januszewska L; Department of Otolaryngology, Central Clinical Hospital of the Ministry of Interior and Administration, Warsaw, Poland.
  • Jakimiuk AA; Department of Plastic Surgery, Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland.
  • Oleksik T; Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland.
  • Pokulniewicz M; Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland.
  • Wierzba W; Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland; University of Humanities and Economics in Lodz, Satellite Campus in Warsaw, Warsaw, Poland.
  • Kozlowski K; Department of Constitutional Law, Jagiellonian University in Krakow, Krakow, Poland.
  • Jakimiuk AJ; Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland; Center for Reproductive Health, Institute of Mother and Child, Warsaw, Poland.
Bosn J Basic Med Sci ; 22(6): 1005-1015, 2022 Oct 23.
Article in English | MEDLINE | ID: covidwho-1893461
ABSTRACT
Coronavirus disease 2019 (COVID-19) was declared a pandemic and has spread around the globe, unsparingly affecting vulnerable populations. Effective prevention measures for pregnant women, who are particularly affected, include early identification of those patients at risk of developing in-hospital complications, and the continuous improvement of maternal-fetal treatment strategies to ensure the efficient use of health resources. The objective of our retrospective study was to determine which patient biomarkers on hospital admission correlate with disease severity as measured by disease course classification, the need for oxygen supplementation and higher demand for oxygen, the need for mechanical ventilation, intensive care unit admission, and length of hospital stay. Analysis of 52 PCR SARS-CoV-2 positive pregnant women revealed that the median date of hospital admission was the 30th gestational week, with dyspnoea, cough, and fever as the leading symptoms. The presence of diabetes and hypertension predisposed pregnant women to the severe course of illness. Lung involvement shown by CT scans on admission correlated with the greater clinical severity. The main laboratory predictors of disease progression were lymphocytopenia, hypocalcemia, low total cholesterol, low total protein levels, and high serum levels of C-reactive protein, ferritin, interleukin-6, glucose, lactate dehydrogenase, procalcitonin, and troponin I. Further research with a larger cohort of pregnant women is needed to determine the utility of these results for everyday practice.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Female / Humans / Pregnancy Language: English Journal: Bosn J Basic Med Sci Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: Bjbms.2022.7181

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Female / Humans / Pregnancy Language: English Journal: Bosn J Basic Med Sci Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: Bjbms.2022.7181