Evaluation of Endothelial Dysfunction in COVID-19 With Flow-Mediated Dilatation. / Avaliação da Disfunção Endotelial em Casos de COVID-19 com Dilatação Fluxo-Mediada.
Arq Bras Cardiol
; 119(2): 319-325, 2022 08.
Article
in English, Portuguese
| MEDLINE | ID: covidwho-1893709
ABSTRACT
BACKGROUND:
Inflammation is known to play a crucial role in many diseases, including COVID-19.OBJECTIVE:
Using flow-mediated dilatation (FMD), we aimed to assess the effects of inflammation on endothelial function in COVID-19 patients.METHODS:
This study was conducted with a total of 161 subjects, of whom 80 were diagnosed with COVID-19 within the last six months (comprising 48 women and 32 men with a mean age of 32.10 ± 5.87 years) and 81 were healthy controls (comprising 45 women and 36 men with a mean age of 30.51 ± 7.33 years). We analyzed the findings of transthoracic echocardiography and FMD in all subjects. All results were considered statistically significant at the level of p < 0.05.RESULTS:
The echocardiography and FMD of the COVID-19 group were performed 35 days (range 25-178) after diagnosis. There was no statistically significant difference in echocardiographic parameters. Differently, FMD (%) was significantly higher in the control group (9.52 ± 5.98 vs. 12.01 ± 6.18, p=0.01). In multivariate analysis with the forward stepwise model, FMD was significantly different in the control group compared to the COVID-19 group (1.086 (1.026 - 1.149), p=0.04). A Spearman's correlation test indicated that FMD (r=0.27, p=0.006) had a weak positive correlation with the presence of COVID-19.CONCLUSION:
Our findings point to COVID-19-induced endothelial dysfunction, as assessed by FMD, in the early recovery phase.RESUMO
FUNDAMENTO Sabe-se que a inflamação desempenha um papel crucial em muitas doenças, incluindo a COVID-19. OBJETIVO:
Utilizando a dilatação fluxo-mediada (DFM), objetivou-se avaliar os efeitos da inflamação na função endotelial de pacientes com COVID-19.MÉTODOS:
Este estudo foi realizado com um total de 161 indivíduos, dos quais 80 foram diagnosticados com COVID-19 nos últimos seis meses (48 mulheres e 32 homens com idade média de 32,10±5,87 anos) e 81 eram controles saudáveis (45 mulheres e 36 homens com idade média de 30,51±7,33 anos). Os achados do ecocardiograma transtorácico e da DFM foram analisados em todos os indivíduos. Resultados com p<0,05 foram considerados estatisticamente significantes.RESULTADOS:
O ecocardiograma e a DFM do grupo COVID-19 foram realizados 35 dias (intervalo 25178) após o diagnóstico. Não houve diferença estatisticamente significativa nos parâmetros ecocardiográficos. Em contraste, a DFM (%) foi significativamente maior no grupo controle (9,52±5,98 versus 12,01±6,18; p=0,01). Na análise multivariada com o modelo stepwise progressivo, a DFM foi significativamente diferente no grupo controle em relação ao grupo COVID-19 (1,086 (1,0261,149), p=0,04). O teste de correlação de Spearman indicou que a DFM (r=0,27; p=0,006) apresentou correlação positiva fraca com a presença de COVID-19.CONCLUSÃO:
Os achados deste estudo apontam para disfunção endotelial induzida por COVID-19, avaliada por DFM, na fase inicial de recuperação.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Vascular Diseases
/
COVID-19
Type of study:
Experimental Studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Young adult
Language:
English
/
Portuguese
Journal:
Arq Bras Cardiol
Year:
2022
Document Type:
Article
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