Collection and quality characteristics of Coronavirus Disease 2019 convalescent plasma
Chinese Journal of Biologicals
; 34(6):699-703, 2021.
Article
in Chinese
| EMBASE | ID: covidwho-1894085
ABSTRACT
Objective To explore the application and safety of apheresis technology in collection of Coronavirus Disease 2019 (COVID-19) convalescent plasma (CP), and to analyze the quality characteristics of the plasma. Methods The general data of COVID-19 convalescent plasma (CP) donors, including gender, age, date of discharge or release from medical isolation, were collected based on informed consent. After physical examination, the CP was collected by apheresis technology with plasma separator, inactivated with methylene blue, and determined for severe acute respiratory symptom Coronavirus 2 (SARS-CoV-2) nucleic acid and specific antibody (RBD-IgG) against SARS-CoV-2. Results The collection process went well, and no serious adverse events related to plasma collection were reported during or after the collection. The average age of COVID-19 CP donors was 38 years (n = 933). The distributions of blood groups A, B, AB and 0 in RhD (+) COVID-19 CP were 33. 4%, 29. 2%, 10% and 27. 2% respectively. The plasma donation date was 18 d from the discharge date in average. All the test results of SARS-CoV-2 nucleic acid in CP were negative, while the proportion of plasma samples at SARS-CoV-2 antibody titer of more than 1 160 was 92. 60%. Conclusion Apheresis technology was safe and reliable. The COVID-19 CP contained high titer antibody. Large-scale collection and preparation of inactivated plasma against SARS-CoV-2 played an important role in the treatment of COVID-19.
apheresis; article; blood group A; circulation; controlled study; coronavirus disease 2019; human; human tissue; major clinical study; physical disease by body function; quality control; virus inactivation; convalescent plasma; endogenous compound; methylene blue; rhesus D antigen; SARS-CoV-2 antibody
Search on Google
Collection:
Databases of international organizations
Database:
EMBASE
Language:
Chinese
Journal:
Chinese Journal of Biologicals
Year:
2021
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS