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Adult paroxysmal cold hemoglobinuria following mRNA COVID-19 vaccination.
Misawa, Kyohei; Yasuda, Hajime; Koyama, Daisuke; Inano, Tadaaki; Inoguchi, Akemi; Shirasu, Chinami; Takano, Hina; Iwao, Noriaki; Ando, Miki; Koike, Michiaki.
  • Misawa K; Department of Hematology Juntendo University Shizuoka Hospital Izunokuni Shizuoka Japan.
  • Yasuda H; Department of Hematology Juntendo University Graduate School of Medicine Bunkyo-ku Tokyo Japan.
  • Koyama D; Department of Hematology Fukushima Medical University Fukushima Fukushima Japan.
  • Inano T; Department of Hematology Juntendo University Shizuoka Hospital Izunokuni Shizuoka Japan.
  • Inoguchi A; Department of Clinical Laboratory Medicine Juntndo University Shizuoka Hospital Izunokuni Shizuoka Japan.
  • Shirasu C; Department of Clinical Laboratory Medicine Juntndo University Shizuoka Hospital Izunokuni Shizuoka Japan.
  • Takano H; Department of Hematology Juntendo University Shizuoka Hospital Izunokuni Shizuoka Japan.
  • Iwao N; Department of Hematology Juntendo University Shizuoka Hospital Izunokuni Shizuoka Japan.
  • Ando M; Department of Hematology Juntendo University Graduate School of Medicine Bunkyo-ku Tokyo Japan.
  • Koike M; Department of Hematology Juntendo University Shizuoka Hospital Izunokuni Shizuoka Japan.
EJHaem ; 3(3): 992-995, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-1894606
ABSTRACT
Paroxysmal cold hemoglobinuria (PCH) is an extremely rare subtype of autoimmune hemolytic anemia (AIHA) in adults. PCH is caused by the biphasic Donath-Landsteiner (DL) antibody which fixes complement to red blood cells at low temperatures and dissociates at warmer temperatures, leading to complement-mediated intravascular hemolysis. Autoimmune hematological disorders including AIHA and immune thrombocytopenia have been reported to develop following the mRNA COVID-19 vaccination. However, PCH developing subsequent to mRNA vaccination has never been reported. We report a 59-year-old male who developed PCH approximately a month after his second mRNA COVID-19 vaccination.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report Topics: Vaccines Language: English Journal: EJHaem Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report Topics: Vaccines Language: English Journal: EJHaem Year: 2022 Document Type: Article